1961
DOI: 10.1007/bf02433549
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Zur Pharmakologie des Vitamins B6

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1985
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“…The known and partly accepted association between PLP and seizures became more puzzling when it was shown that the administration of pharmacological doses of vitamin B6 also caused tonic-clonic convulsions (Kraft et al, 1961;Wiechert and Herbst, 1966;Tapia, 1975;Eto et al, 1978;Kouyoumdjian and Ebadi, 1981). These later investigators have shown that the intracerebroventricular injection of PLP (0.125 pmolf10 pl/rat), but not other B6 derivatives (Fig.…”
Section: Vitamin B6 Excess Induces Convulsive Seizuresmentioning
confidence: 98%
“…The known and partly accepted association between PLP and seizures became more puzzling when it was shown that the administration of pharmacological doses of vitamin B6 also caused tonic-clonic convulsions (Kraft et al, 1961;Wiechert and Herbst, 1966;Tapia, 1975;Eto et al, 1978;Kouyoumdjian and Ebadi, 1981). These later investigators have shown that the intracerebroventricular injection of PLP (0.125 pmolf10 pl/rat), but not other B6 derivatives (Fig.…”
Section: Vitamin B6 Excess Induces Convulsive Seizuresmentioning
confidence: 98%