Zur Pharmakologie des 1-Phenyl-2-methylaminopropans (Pervitin)

Hauschild, F

doi:10.1007/bf01998844

Cited by 57 publications

(2 citation statements)

References 21 publications

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“…A stereotyped behaviorwas first reported in animal experiments (HAUSCHILD, 1939;BONHOFF and LEWRENZ, 1954, p.55) and its mediation via dopaminergic activity within the brain has been established (RANDRUP and MUNKVAD, 1965). doses of amphetamine.…”

Section: Stereotyped Behaviormentioning

confidence: 94%

“…Generally there is an initial alerting effect of the drug accompanied by increased exploratory behavior, grooming, rearing, and forward locomotion, later by a decrease in these activities concomitant with various stereotype behaviors, with marked species varations (see . The above description sterns from studies in rats (EHRICH and KRUMBHAAR, 1937;EHRICH et al, 1939;HAUSCHILD, 1938;SEARLE and BROWN, 1938;HEIMSTRA, 1962a, b;SILVERMAN, 1966;RANDRUP and MUNKVAD, 1967a, b;FOG, 1969;SCHI0RRING, 1971;NORTON, 1973), but similar gross behavioral effects have been observed in mice (e.g., GUNN et al, 1939;UTENA, 1966;RANDRUP and MUNKVAD, 1967a;SATINDER et al, 1970;RICHARD-SON et al, 1972), guinea pigs (UTENA et al, 1959;UTENA, 1966;RANDRUP and MUNKVAD, 1967a;LEWANDER, 1971 c;, rabbits (EHR ICH et aL 1939;BRODlE and SHORE, 1957;LAVERTY and SHARMAN, 1965), cats (EHRICH et al, 1939;WHITE et al, 1961;LAVERTY and SHARMAN, 1965;NORTON, 1967;RANDRUP and MUNKVAD, 1967a;ELLINWOOD and ESCALANTE, 1970a;ELLINWOOD, 1971 b;BELOZERTSEV, 1974), dogs (EHRICH et al, 1939;CHISTONI and BECCARI, 1940;AccoRNERo, 1947;LAVERTY and SHARMAN, 1965;WILLNER et al, 1970;BUYNISKI et al, 1974), monkeys (EHRICH et al, 1939;FITZ-GERALD...…”

Section: Gross Behaviormentioning

confidence: 99%

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General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

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Amphetamine and related central stimulant drugs are derivatives of ß-phenylethylamine (Table 1) and are thus relatively simple organic bases. The general ßphenylethylamine skeleton is one which amphetamine shares with the neurotransmitters noradrenaline, adrenaline, and dopamine. Phenylethylamine itselfhas central stimulant properties, but has an extremely short half-life in the body due to rapid metabolism by monoamine oxidase (MAO). Amphetamine has, due to steric hindrance by the ex-methyl group, much less affinity for MAO and therefore has a longer half-Iife.Most amphetamines have cardiovascular, psychomotor stimulant, hyperthermic, and anorexigenic actions. All of the structural features of amphetamine are important far its spectrum of pharmacologic activity. Any alteration may enhance, diminish, or attenuate one or several components in the actions of the parent drug. (1) Substitution of the phenyl ring, (2) alteration of the length of the side chain, (3) substitution on the primary nitrogen group, (4) substitution of the ex-and ß-carbon atoms, and (5) their absolute configuration have been studied and will be briefly discussed here. For a more thorough review on the subject the reader is referred to the papers by BIEL (1970), vANRossuM and SIMONS (1969) and VREE (1973. The effect of ring and side-chain substitution on distribution and elimination of the amphetamines has been discussed by BECKETT and BROOKES (1970). recently reviewed the biochemical pharmacology of the amphetamines. The metabolism and disposition of methylphenidate were reported by F ARAJ et al.

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Section: Stereotyped Behaviormentioning

confidence: 94%

Section: Gross Behaviormentioning

confidence: 99%

General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

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CNS Stimulants

Nichols¹

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter briefly describes the development, structure‐activity relationships, and mechanism of action for the important psychostimulants such as amphetamines, methylphenidate, and cocaine. Derived from natural products known for centuries, at low doses these drugs lead to increased arousal, improved performance on tasks of vigilance and alertness, and a sense of self‐confidence and well‐being. High doses can produce feelings of elation or euphoria, and result in profound abuse liability. This chapter reviews the current and future use of psychostimulants, as well as other drugs that cause CNS arousal, albeit by different mechanisms.

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CNS Stimulants

Nichols

2010

Burger's Medicinal Chemistry and Drug Discovery

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This chapter briefly describes the development, structure–activity relationships, and mechanism of action for the important psychostimulants such as amphetamines, methylphenidate, and cocaine. Derived from natural products known for centuries, at low doses these drugs lead to increased arousal, improved performance on tasks of vigilance and alertness, and a sense of self‐confidence and well being. High doses can produce feelings of elation or euphoria, and result in profound abuse liability. This chapter reviews the current and future use of psychostimulants, as well as other drugs that cause CNS arousal, albeit by different mechanisms.

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Zur Pharmakologie des 1-Phenyl-2-methylaminopropans (Pervitin)

Cited by 57 publications

References 21 publications

General Pharmacology of Amphetamine-Like Drugs

General Pharmacology of Amphetamine-Like Drugs

CNS Stimulants

CNS Stimulants

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