Zur pathologischen Anatomie des peripherischen Sympathicus

Wohlwill, Friedrich

doi:10.1007/bf01660137

Cited by 40 publications

(3 citation statements)

References 5 publications

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“…Herzog (1928), Wohlwill (1928), andHechst andNussbaum (1931) found Lewy bodies in the ganglion cells of the sympathetic vertebral chain in paralysis agitans, and were therefore the first investigators to encounter Lewy bodies outside the central nervous system. They do not indicate whether Lewy bodies were also present in the central nervous system in these cases.…”

mentioning

confidence: 99%

The Distribution of Lewy Bodies in the Central and Autonomic Nervous Systems in Idiopathic Paralysis Agitans

Jäger¹,

Bethlem²

1960

Journal of Neurology, Neurosurgery & Psychiatry

261

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mentioning

confidence: 99%

The Distribution of Lewy Bodies in the Central and Autonomic Nervous Systems in Idiopathic Paralysis Agitans

Jäger¹,

Bethlem²

1960

Journal of Neurology, Neurosurgery & Psychiatry

261

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“…Constipation, which is seen in up to 80% of PD patients, 2 was described by James Parkinson in his initial case reports describing the disease 3 . Lewy pathology, the pathological hallmark of PD, was first observed in the colon in 1928 4,5 …”

Section: Introduction To Gut‐first Pd and Review Objectivesmentioning

confidence: 99%

“…3 Lewy pathology, the pathological hallmark of PD, was first observed in the colon in 1928. 4,5 More recently, Braak and colleagues theorized that PD may begin in the gut. [6][7][8] This theory was based on observations that Lewy pathology, now termed Lewy-type synucleinopathy (LTS) spread regionally in the brain from areas more closely connected to the periphery in association with disease duration.…”

mentioning

confidence: 99%

Experimental models of gut‐first Parkinson's disease: A systematic review

Videlock

Xing

Yehya

et al. 2023

Neurogastroenterology Motil

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Background There is strong support from studies in humans and in animal models that Parkinson's disease (PD) may begin in the gut. This brings about a unique opportunity for researchers in the field of neurogastroenterology to contribute to advancing the field and making contributions that could lead to the ability to diagnose and treat PD in the premotor stages. Lack of familiarity with some of the aspects of the experimental approaches used in these studies may present a barrier for neurogastroenterology researchers to enter the field. Much remains to be understood about intestinal‐specific components of gut‐first PD pathogenesis and the field would benefit from contributions of enteric and central nervous system neuroscientists. Purpose To address these issues, we have conducted a systematic review of the two most frequently used experimental models of gut‐first PD: transneuronal propagation of α‐synuclein preformed fibrils and oral exposure to environmental toxins. We have reviewed the details of these studies and present methodological considerations for the use of these models. Our aim is that this review will serve as a framework and useful reference for neuroscientists, gastroenterologists, and neurologists interested in applying their expertise to advancing our understanding of gut‐first PD.

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