Zur Pathologie des argyrophilen Helle-Zellen-Organes im Bronchialbaum des Menschen

Feyrter, F

doi:10.1007/bf00955103

Cited by 88 publications

(24 citation statements)

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“…The first description of the neuroendocrine cell, by Pretl more than 50 years ago (Pretl 1944), was followed by Feyrter's concept of the 'Helle-Zellen System', or a diffuse neuroendocrine system (Feyrter 1951). Pearse (1969) developed this concept further as the amine precursor uptake and decarboxylation (APUD) system.…”

Section: Historical Backgroundmentioning

confidence: 99%

Neuroendocrine cells in tumour growth of the prostate.

Abrahamsson¹

1999

Endocrine-Related Cancer

227

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The prognostic significance of neuroendocrine differentiation in prostatic malignancy is controversial, but the results of recent studies with markers such as chromogranin A and neurone-specific enolase suggest that neuroendocrine differentiation, as reflected by increased tissue expression or blood concentrations of these neuroendocrine secretory products, is associated with a poor prognosis, tumour progression, and androgen independence. As all malignant neuroendocrine cells are devoid of androgen receptors and the expression of neuroendocrine cells is not suppressed by androgen ablation, clonal propagation of androgen receptor-negative neuroendocrine cells may have an important role in the development of androgen-independent prostatic carcinoma. This has significant implications for the treatment of prostate cancer, because several of the hormones that are secreted by neuroendocrine differentiated, malignant prostatic cells are potential candidates for use in drug treatment. A limited number of hormones have been tested in this context, in particular somatostatin, bombesin, and serotonin. As there is currently no successful treatment for differentiated prostate cancer, new therapeutic procedures and trials need to be developed to test drugs based on Endocrine-Related Cancer (1999) 6 503-519 neuroendocrine hormones or their antagonists.

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Section: Historical Backgroundmentioning

confidence: 99%

Neuroendocrine cells in tumour growth of the prostate.

Abrahamsson¹

1999

Endocrine-Related Cancer

227

198

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“…A distinct population of granulated cells posessing both endocrine and neural characteristics has been recognized in the respiratory epithelium for over thirty years (8,10). These pulmonary neuroendocrine cells (PNEC) are identified in greatest numbers during the neonatal period (19,24) and are situated near both pulmonary vessels and nerves (8,10,20,23,28).…”

Section: Speculationmentioning

confidence: 99%

Pulmonary Neuroendocrine Cells in Hyaline Membrane Disease and Bronchopulmonary Dysplasia

et al. 1982

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Summary munoreactivity (2). Bombesin, a 14 amino acid peptide, is aThe number and distribution of bombesin immunoreactive pulmonary neuroendocrine cells (PNEC) in fetuses and infants up to 6 months of age was determined on postmortem lung specimens. Individual cells and clusters of cells (neuroepithelial bodies) were found in airways of all sizes, although greater than 95% of the positive cells were located in bronchioles, terminal bronchioles, and respiratory bronchioles. These infants were separated into two groups. In control infants, who died primarily from noncardiopulmonary causes, bombsin immunoreactive neuroendocrine cells were identified throughout the latter half of gestation. As gestation advanced, progressively more positive bronchioles/cm2 of lung tissue and cells/bronchiole were identified. In these control infants, the number of positive bronchioles/cm2 and cells/bronchiole were at the highest level at or near the time of delivery and then gradually declined throughout the first 6 months of life. In contrast, infants who died of acute hyaline membrane disease (1-7 days of life) or bronchiopulmonary dysplasia (2 wk to 6 months of life) demonstrated marked differences in the number of identifiable bombesin immunoreactive neuroendocrine cells when compared to control infants. In early hyaline membrane disease, the number of positive bronchioles/cm2 and cells/bronchiole was markedly decreased. During the transition to chronic bronchopulmonary dysplasia, there appeared to be a marked increase in the number of bombesin immunoreactive cells. The peak number of cells occurred a t 2-3 months of life, when substantially more bombesin-immunoreactive cells could be identified in children with bronchopulmonary dysplasia than control infants of similar age.

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“…The cytological and cytochemical characteristics of the individual cells are comparable to single, isolated cells distributed throughout the bronchopulmonary tree including the alveoli (CooK and KING, 1969;CUTZ and CONEN, 1970;JEFFERY and REID, 1973;WASANO and YAMAMOTO, 1978). Attention was first drawn to these cells in the respiratory tract as a result of their lack of affinity for haematoxylin and eosin, a fact which increased the contrast between them and the surrounding, more heavily stained epithelium (FEYRTER, 1938). Consequently the cells were termed clear cells or "helle Zellen".…”

mentioning

confidence: 87%

“…Moreover, in many instances the granules were blackened after silver nitrate without the use of an exogenous reducer, a condition referred to as argentaffin (HAMPERL, 1952;LAUWER-YNS and PEUSKENS, 1972;SCHEUERMANN et al, 1983). The NEBs were also argyrophilic as reduced silver was deposited in the general cytoplasm after treatment with silver nitrate followed by an exogenous reducing solution (HAMPERL, 1952;FEYRTER, 1954). The latter technique revealed a further interesting aspect in that they were associated with nerve fibres which penetrated the epithelium (FROHLICH, 1949;LAUWERYNS and PEUSKENS, 1972).…”

mentioning

confidence: 99%

“…The NEBs of all vertebrates studied receive an extensive innervation from unmyelinated axons which either penetrate the subepithelial basement membrane or reside in close proximity not only to this membrane but also the underlying complex of capillaries (FEYRTER, 1938;HUNG et al, 1973;LA-UWERYNS et al, 1970). Experiments on mammals and birds including electrical stimulation, loading with tritiated amino acids and lesions of the principal nerves have shown that these axons are derived from the vagus nerve (BOWER et al,1978;LAWERYNS et al, 1987).…”

mentioning

confidence: 99%

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