Zur Pathogenese der Chondrodermatitis nodularis chron. helicis

Frequency and etiology of chondrodermatitis nodularis chronica helicis

“…During the time bilateral occurrence or multiple lesions of CNH was reported just for a few patients. [12,22,23] In our study, right ear and the superior pole of the helix are preferentially affected by CNH similar with published literature. Several theories have been suggested including trauma from cold, actinic damage, or prolonged and excessive pressure.…”

“…Uptil et al [21] maintained the perichondrial vasculitis theory which was initially hypothesized by Halter. [22] They claimed that arteriolar narrowing in perichondrium region of the pinna most remote from arterial blood supply and this has lead to ischemic changes and death of the metabolically active underlying cartilage with necrosis and extrusion leading to a cycle of severe local inflammation secondary to a foreign body reaction. We agree with this theory and decided to confirm it by searching a systemic vascular pathology for clearing this situation in the CNH patients.…”

Advances in the understanding of chondrodermatitis nodularis chronica helices: the perichondrial vasculitis theory

“…A large case series (100 patients) in the literature was published in 1954, 6 the authors broadly covered all clinical and histopathological aspects of the condition. Our study builds upon this work and explores the vasculitis theory suggested by their observations and first suggested by Halter in 1936 7 …”

“…20,21 This is the first report of specific perichondrial arteriolar changes as the possible cause of underlying cartilage necrosis resulting in CNCH. Vasculitis, inflammation of the vessel wall, as a possible cause for this condition was initially hypothesised by Halter (1936) but this line of investigation was not pursued until our recent histo-pathological study. 6 The perichondrial vasculitis theory is outlined in Fig.…”

“…Our study builds upon this work and explores the vasculitis theory suggested by their observations and first suggested by Halter in 1936. 7 The aetiology of the disease is unknown. In early reports, the majority of affected individuals were middle-aged to elderly males and the disease was also described in a small number of females; [8][9][10][11] however, more recent studies have quoted a higher prevalence among women with similar age distribution.…”