Zur Orthologie und Pathologie Panethscher K�rnerzellen

Otto, Herwart F.; Fett, Rüdeger

doi:10.1007/bf00543155

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…Gastric metaplasia in the colon and rectum is rare in normal individuals [Debas et al, 1980;Shimer, 1980;Willis, 19621. Small intestinal metaplasia of the large intestine could be easily overlooked because of difficulties in scoring for it in standard pathological examination [Lauren, 19611; its occurrence is likely since there are reports of the presence of otherwise rare Paneth cells in colonic tumors and argentaffin and Paneth cells typical of the small intestine are present in cases of ulcerative colitis [Gibbs, 1967;Herzog, 1937;Holmes, 1965;Otto and Fett, 1972;Paterson and Watson, 1960;Symonds, 1974;Watson and Roy, 19601. One wonders what the direct physiological consequences of small intestinal metaplasia in the colon would be since, at least in the stomach, such foci appear active in their characteristic metabolism and absorptive capacities [Morgan, 1982;Hartman, 19821. Small intestinal tissue placed in the colon would be subject to products of novel and intensive bacterial metabolism collectively approaching that of the the entire human liver.…”

Section: Metaplasias In the Large Intestinementioning

confidence: 99%

Mutagens: Some possible health impacts beyond carcinogenesis

Hartman

1983

Environ. mutagen

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Considerable attention is currently being given to the roles of environmental and endogenous mutagens in tumor induction and in tumor progression through the abilities of mutagens to induce one or another kind of somatic mutation. It is proposed here that mutagens, also through induction of somatic mutations, initiate a spectrum of additional, much more common, focal lesions that are important to the human condition. While individually they are of relative insignificance and thus neglected by many clinicians, the functional attributes of these focal lesions have important impacts on human physiology and thus contribute substantially to the process of aging. Additionally, one individual focus may progress to an extent that it produces clinically recognizable symptoms and may even jeopardize the carrier's life. The ultimate and developed expression of these lesions is heterogeneous, is far removed in time from initial induction, and relies on additional host and environmental factors for expression; therefore, the possible role of somatic mutation is readily overlooked. The focal lesions reviewed are fibrous atherosclerotic plaques, senile cataracts, and metaplasias. Literature that implicates metaplasias as precursor or as predisposing lesions in the ultimate formation of gallstones, duodenal ulcers, and adenocarcinomas is summarized.

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Section: Metaplasias In the Large Intestinementioning

confidence: 99%

Mutagens: Some possible health impacts beyond carcinogenesis

Hartman

1983

Environ. mutagen

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Paneth Cells in Experimental Amyloidosis

Ahonen

Penttilä

Klinge

1977

Scandinavian Journal of Gastroenterology

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Incidence of Paneth cells in colorectal adenomas of Japanese descendants in Hawaii

Wada

Kuwabara

Suda

1994

J of Gastro and Hepatol

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The main purpose of the present study was to demonstrate the incidence of Paneth cells in colorectal tubular adenomas of Japanese descendants in Hawaii. Paneth cells were found in 73 of 322 adenomas (22.7%) of Japanese descendants in Hawaii. The incidence of Paneth cells in adenomas located from the caecum to the transverse colon was significantly higher than that of adenomas from the descending colon to the rectum. The same trend of a higher incidence of Paneth cells in adenomas from the caecum to the transverse colon was observed in Japanese descendants and Caucasian residents in Hawaii and in native Japanese. The incidence of Paneth cells in adenomas of Japanese descendants in Hawaii was higher than that of native Japanese, and also that of Caucasian residents was higher than that of native Japanese.

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Zur Orthologie und Pathologie Panethscher K�rnerzellen

Cited by 4 publications

References 42 publications

Mutagens: Some possible health impacts beyond carcinogenesis

Mutagens: Some possible health impacts beyond carcinogenesis

Paneth Cells in Experimental Amyloidosis

Incidence of Paneth cells in colorectal adenomas of Japanese descendants in Hawaii

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