Zur Lebensdauer fetaler Erythrocyten im m�tterlichen Kreislauf nach fetomaternaler Transfusion

Kleihauer, E.; Brandt, Guilherme

doi:10.1007/bf01486030

Cited by 19 publications

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“…The lifespans of our 40 week gestation cases of 83 and 89 day,s are a little longer than those found by Kleihauer and Brandt (1964). This may reflect the virtual absence of mechanical manipulation of the transfused blood in fetomaternal haemorrhage compared with that necessary in the manual injection method used in that study and that of Zipursky (1965).…”

Section: Discussionmentioning

confidence: 54%

“…Providing that there is no immunological impairment to the survival of the fetal cells, their demonstration allows us to follow their persistence in the maternal circulation after feto-maternal macrotransfusion, to determine their lifespan there.A report of this type of study (Renaer ef al., 1976) showed that erythrocytes of a 34 week gestation fetus were no longer detectable 54 days after its intrauterine death due to protracted transplacental haemorrhage of approximately 450 ml of blood. Zipursky (1965) injected cord blood cells into compatible adults and found their lifespan to range from 56 to 105 days, while Kleihauer and Brandt (1964) in a similar experiment found a lifespan of 70 to 80 days.In this study the results of following three more cases of feto-maternal macrotransfusion are presented to provide a more complete picture of fetal erythrocyte lifespan in the third trimester of pregnancy.…”

mentioning

confidence: 99%

“…A report of this type of study (Renaer ef al., 1976) showed that erythrocytes of a 34 week gestation fetus were no longer detectable 54 days after its intrauterine death due to protracted transplacental haemorrhage of approximately 450 ml of blood. Zipursky (1965) injected cord blood cells into compatible adults and found their lifespan to range from 56 to 105 days, while Kleihauer and Brandt (1964) in a similar experiment found a lifespan of 70 to 80 days.…”

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Fetal Erythrocyte Lifespan

Harrison¹

1979

J Paediatrics Child Health

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Harrison, K. L. (1979) Aust. Paediatr. J., 15,[96][97]. Fetal erythrocyte lifespan. The demonstration of fetal erythrocytes in the maternal circulation by the Kleihauer technique after feto-maternal macrotransfusion provides a means of measuring the lifespan of those cells produced at the time of the haemorrhage. Two cases of massive feto-maternal haemorrhage at 40 weeks gestation and one at 36 weeks gestation are used, together with a published case at 34 weeks gestation, to show that erythrocyte lifespan is quite short in fetal life and increases during the third trimester to be 80 to 90 days in a full term infant.There have been a number of studies using radioisotope tagging of fetal erythrocytes to determine their lifespan but results have varied. Foconi and Sjolin (1959) found that fetal cells had a reduced lifespan and an increased 5ICr elution rate compared with adult cells, while Kaplan and Ku Shin Hsu (1961) found the red cell lifespan and 51Cr elution rate of full term fetal cells to be the same as adult cells. Most workers agree that the red cells of premature infants have a reduced lifespan. Based on a study of erythrokinetics, Bratteby et al. (1968) mathematically determined the mean lifespan of full term fetal cells to be between 45 and 70'days, a value accepted by a recent authoritative summary of available data (Oski and Schwartz, 1972).Fetal erythrocytes can be easily demonstrated in a film of maternal blood by the acid-elution and staining method first described by Kleihauer et a/. (1957). Providing that the fetal cells are ABO compatible with those of the mother, fetomaternal haemorrhages can be readily quantitated by counting fetal cells demonstrated in this manner. At birth, 50-65% of haemoglobin synthesis is of the fetal type (Oski and Naiman, 1972), so erythrocytes produced at this time should be readly demonstrable by this technique.In the puerperium, fetal erythrocytes can be detected in the circulation of up to 50% of mothers (Woodrow and Donohoe, 1968) but in most cases these are of very small magnitude. Providing that there is no immunological impairment to the survival of the fetal cells, their demonstration allows us to follow their persistence in the maternal circulation after feto-maternal macrotransfusion, to determine their lifespan there.A report of this type of study (Renaer ef al., 1976) showed that erythrocytes of a 34 week gestation fetus were no longer detectable 54 days after its intrauterine death due to protracted transplacental haemorrhage of approximately 450 ml of blood. Zipursky (1965) injected cord blood cells into compatible adults and found their lifespan to range from 56 to 105 days, while Kleihauer and Brandt (1964) in a similar experiment found a lifespan of 70 to 80 days.In this study the results of following three more cases of feto-maternal macrotransfusion are presented to provide a more complete picture of fetal erythrocyte lifespan in the third trimester of pregnancy.

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Section: Discussionmentioning

confidence: 54%

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confidence: 99%

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confidence: 99%

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