Zur Kenntniss des Thiourazols

Freund, Martin; Schander, Alfred

doi:10.1002/cber.18960290322

Cited by 10 publications

(2 citation statements)

References 2 publications

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“…5-Amino-3H-1,3,4-thiadiazol-2-one ( 13 ) was prepared first, and then, based on 13 , 1,3,4-thiadiazole derivative 3 was obtained. The synthesis of 13 was not initially successful, with the synthetic approach based on Freund and Schander's procedure [29]. They claimed that 5-amino-3H-1,3,4-thiadiazol-2-one (13) was prepared by heating 2-thiodiurea with concentrated hydrochloric acid.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and In Vitro Evaluation of Novel Acyclic and Cyclic Nucleoside Analogs with a Thiadiazole Ring

Zhao

McCarthy

Párkányi

2013

ISRN Organic Chemistry

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The synthesis of six thiadiazole nucleoside analogs is reported: 5-diacetylamino-1,2,4-thiadiazol-3-one (1), 5-amino-2- (tetrahydrofuran-2-yl)-1,2,4-thiadiazol-3-one (2), 5-amino-3-[(2′-hydroxyethoxy)methyl]-1,3,4-thiadiazol-2-one (3), 5-amino-3-(4′-hydroxy-2′-hydroxymethyl-butyl)-1,3,4-thiadiazole-2-thione (4), (R)-5-amino-3-(2′,3′-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (5), and (S)-5-amino-3-(2′,3′-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (6). The synthesis, characterization, and properties of these new synthesized thiadiazole derivatives are discussed. A dimerization of 5-amino-3H-1,3,4-thiadiazole-2-thione (14) by sodium nitrite resulting in di-(5-amino-1,3,4-thiadiazol-2-yl) disulfide (19) is also reported. The preliminary in vitro evaluation of these newly synthesized compounds is discussed.

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Section: Resultsmentioning

confidence: 99%

Synthesis and In Vitro Evaluation of Novel Acyclic and Cyclic Nucleoside Analogs with a Thiadiazole Ring

Zhao

McCarthy

Párkányi

2013

ISRN Organic Chemistry

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“…2-Amino-5hydroxy-1,3,4-thiadiazole(VI), m.p. 177°C ., was synthesized by the method of Freund and Schander (1896). 1,3,4-Thiadiazol-2,5-dithiol(VII), m.p.…”

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confidence: 99%

Herbicidal activity of 1,3,4-thiadiazole derivatives

Kubo¹,

Sato²,

Hamura³

et al. 1970

J. Agric. Food Chem.

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A number of related 1,3,4-thiadiazole derivatives have been synthesized and their herbicidal activities have been evaluated by pre-emergence, postemergence, and irrigated water treatment methods. Some l-substituted-3-(5-substituted-l,3,4-thiadiazol-2-yl)ureas showed excellent herbicidal activity. This activity depends upon the molecular size of the substituent in the 5-position of 1,3,4-thiadiazole ring. In particular, activity is maximized when the substituent is the tertiary-butyl group, while replacement of the O atom in the urea moiety with a S atom resulted in decreased herbicidal activity. Further correlations of chemical structure to herbicidal activity are discussed.

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Derivatives of the 1,3,4‐Thiadiazoles and Their Selenium Analogs

1952

Chemistry of Heterocyclic Compounds: A Series of Monographs

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Zur Kenntniss des Thiourazols

Cited by 10 publications

References 2 publications

Synthesis and In Vitro Evaluation of Novel Acyclic and Cyclic Nucleoside Analogs with a Thiadiazole Ring

Synthesis and In Vitro Evaluation of Novel Acyclic and Cyclic Nucleoside Analogs with a Thiadiazole Ring

Herbicidal activity of 1,3,4-thiadiazole derivatives

Derivatives of the 1,3,4‐Thiadiazoles and Their Selenium Analogs

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