Zur Kenntniss des Anfangsstadiums des Lichen ruber planus

Pinkus, Felix

doi:10.1007/bf01987129

Cited by 10 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…a loosening of the attachment by undermining and compromising the connecting epithelial cells." 20 Those findings correspond to the modern concept of an impairment of keratocytes of the basal layer by lymphocytes (Fig. 10).…”

supporting

confidence: 84%

The Life and Work of Felix Pinkus—A Reminder on the Occasion of His 150th Birthday

Weyers¹

2019

The American Journal of Dermatopathology

View full text Add to dashboard Cite

FIGURE 18. A, Frontispiece of Pinkus's chapter on "The Normal Anatomy of the Skin" in the first volume of Jadassohn's "Handbook of Skin and Venereal Diseases," published in 1932. B, A figure from Pinkus's chapter on the anatomy of the skin in Jadassohn's Handbook showing the essential anatomical features of a hair follicle with associated sebaceous glands and muscles of hair erection. Both from 15 .

show abstract

supporting

confidence: 84%

The Life and Work of Felix Pinkus—A Reminder on the Occasion of His 150th Birthday

Weyers¹

2019

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…In some parts of the skin, MCs are surrounded by morphologically distinct columnar KCs at the base of a stratified squamous epithelium that is thicker than the surrounding epidermis. This specialized epidermal structure was named a touch dome (TD, or haarscheibe) based on its speculated function . Keratin 8 (K8) and Keratin 18 (K18) are established markers for MCs in late foetal and adult skin.…”

Section: Merkel Cells and Touch Domes In Mammalian Skinmentioning

confidence: 99%

Merkel cells and touch domes: more than mechanosensory functions?

Xiao

Williams

Brownell

2014

Experimental Dermatology

View full text Add to dashboard Cite

The touch dome is an innervated structure in the epidermis of mammalian skin. Composed of specialized keratinocytes and neuroendocrine Merkel cells, the touch dome has distinct molecular characteristics compared to the surrounding epidermal keratinocytes. Much of the research on Merkel cell function has focused on their role in mechanosensation, specifically light-touch. Recently, more has been discovered about Merkel cell molecular characteristics and their cells of origin. Here we review Merkel cell and touch dome biology, and discuss potential functions beyond mechanosensation.

show abstract

“…35,[43][44][45][46] Much of what we know about the development of Merkel cells comes from studies of mouse hairy skin, where Merkel cells are organized at the base of the epidermis together with specialized columnar keratinocytes located around primary hair follicles in crescent-shaped structures termed Haarscheiben or touch domes (TDs) based on their speculative function. 6,25,27,47 In human skin, TDs can be found in hairy anatomical locations and are characterized by KRT17-expressing specialized keratinocytes located in the lower and middle layers of the epidermis, above the Merkel-neurite complexes. 28,48,49 TD keratinocytes differ from other epidermal keratinocytes and serve as a specialized niche that both regenerates Merkel cells, as well as responsible for maintaining innervation of the Merkel-neurite complexes.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic regulation and signalling pathways in Merkel cell development

Oss-Ronen

Cohen

2021

Experimental Dermatology

View full text Add to dashboard Cite

Merkel cells are specialized epithelial cells connected to afferent nerve endings responsible for light-touch sensations, formed at specific locations in touch-sensitive regions of the mammalian skin. Although Merkel cells are descendants of the epidermal lineage, little is known about the mechanisms responsible for the development of these unique mechanosensory cells. Recent studies have highlighted that the Polycomb group (PcG) of proteins play a significant role in spatiotemporal regulation of Merkel cell formation. In addition, several of the major signalling pathways involved in skin development have been shown to regulate Merkel cell development as well. Here, we summarize the current understandings of the role of developmental regulators in Merkel cell formation, including the interplay between the epigenetic machinery and key signalling pathways, and the lineage-specific transcription factors involved in the regulation of Merkel cell development.

show abstract

Zur Kenntniss des Anfangsstadiums des Lichen ruber planus

Abstract: Aus der hydrotheral0eutischea An~talt der ~Yniver~it~t Berlin.

Cited by 10 publications

References 4 publications

The Life and Work of Felix Pinkus—A Reminder on the Occasion of His 150th Birthday

The Life and Work of Felix Pinkus—A Reminder on the Occasion of His 150th Birthday

Merkel cells and touch domes: more than mechanosensory functions?

Epigenetic regulation and signalling pathways in Merkel cell development

Contact Info

Product

Resources

About