Zur Kenntniss der brenzkatechinähnlichen Substanz in den Nebennieren.

The Chemistry Of Adrenochrome And Related Compounds

“…Variation of the reaction parameters appears to have a considerable effect on the fluorescence characteristics and absorption spectra of the products (c/. 7,50,102,165,185,199,200,268); it was soon apparent that the reaction was not as simple as originally supposed and that variable mixtures of products were produced depending on the reaction conditions employed. Two-dimensional paper chromatography (after elimination of excess ethylenediamine, which interferes with the separation) has shown that the reaction between ethylenediamine and adrenaline gives eighteen products, while that with noradrenaline gives nineteen (184).…”

“…Abel gave the name HO HO A CHOH CH2 CHj I "epinephrine" to the active substance that was liberated from the benzoate by saponification with dilute sulfuric acid (1, 2). Takamine named the active principle that he isolated from the suprarenal gland "adrenaline" (244), and about the same time von Fürth isolated a physiologically active iron derivative of the substance and called it "suprarenin" (102,103,104). Later these products were shoxvn to be more or less pure varieties of the one active constituent (3).…”