Zur Kenntnis des Vitamnis C. Synthese der 6‐Methyl‐l‐arabo‐3‐keto‐hexonsäure‐lactons (l‐Rhamno‐ascorbinsäure)

Synthesis of l-Hexoses

“…l -Sorbose-4-methyl ether was prepared from d -glucose 3-methyl ether via the corresponding sorbitol derivative and microbial oxidation, which was found to be much slower than in the ascorbinic acid synthesis (without the 4- O -methyl) . In connection with studying the biological activity of l -ascorbinic acid the chain-extended l -rhamno-ascorbinic acid was synthesized from l -rhamnosone, which was obtained from l -rhamnose using Fischer’s method . In 1935 Reichstein and Steiger could synthesize the, at the time unknown, l -psicose.…”

“…89 In connection with studying the biological activity of L-ascorbinic acid the chain-extended Lrhamno-ascorbinic acid was synthesized from L-rhamnosone, which was obtained from L-rhamnose using Fischer's method. 90 In 1935 Reichstein and Steiger could synthesize the, at the time unknown, L-psicose. The approach was again microbial oxidation but this time of allitol.…”