Zur intrazytoplasmatischen Injektion (ICSI) von Spermatozoen aus dem Nebenhoden (MESA) und dem Hoden (TESE): Eine retrospektive Analyse von über 500 Behandlungszyklen

Pharmacokinetics, safety, and tolerability of Pentoxifylline intravaginal gel for subfertile/ infertile couples with low sperm quality: phase I randomized controlled clinical trial in healthy women

“…Epididymal and testicular spermatozoa yield similar fertilisation, cleavage and ongoing pregnancy rates using ICSI 927,928 and are both successful for establishing pregnancies. 915,922 Some authors report these success rates as being lower than those achieved by spermatozoa from the ejaculate.…”

“…Various studies have shown that the fecundity rate, clinical pregnancy rate, overall rate of clinical pregnancy rate per embryo transfer or clinical abortions after ICSI using cryopreserved or fresh surgically retrieved spermatozoa are not significantly different. 901,927,936 In one study, 901 the only significant factor appeared to be the age of the woman. [Evidence level 3] Using cryopreserved testicular sperm (cryo-TESE) for ICSI is an effective and successful approach for the treatment of severe testicular insufficiency.…”

“…921 Because cryopreservation of spermatozoa has many additional Fertility: assessment and treatment for people with fertility problems 110 a These studies may include some of the same men advantages (for example, in comparison to the use of native testicular sperm with the necessity of repetitive testicular biopsies), it is routine in the performance of MESA-ICSI and TESE-ICSI. 921,927 Testicular tissue which is intentionally obtained well before any planned ICSI cycle and cryopreserved could then serve as an efficacious sperm source in a subsequent ICSI cycle. This approach should be an alternative to repeated testicular tissue sampling and the availability of spermatozoa is assured before the initiation of ovulation induction.…”