Zur Immunpathogenese perimyokardialer Erkrankungen

Maisch, Bernhard

doi:10.1007/978-3-642-95517-4_8

Cited by 2 publications

(3 citation statements)

References 102 publications

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“…Hypocomplementemia was determined in the respective studies according to established procedures [125]. Immunohistology of cardiac valves and myocardial tissue followed routine procedures [69,74,81].…”

Section: Methodsmentioning

confidence: 99%

“…The immune response in infective endocarditis, as in any form of inflammation [56], is part of a "network" that has systemic and cardiac sites of action, and which comprises anti-microbial and autoreactive components. It involves predisposition and genetic factors of the individual and has to take into account the tropism and virulence of the infective agent [21,22,71,72,74,76,[79][80][81].…”

Section: Introductionmentioning

confidence: 99%

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Autoreactive mechanisms in infective endocarditis

Maisch

1989

Springer Semin Immunopathol

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Summary.Infective endocarditis is not a simple interaction between a microbial agent and a cardiac valve. For the infection of a non-bacterial thrombotic vegetation, predisposition is required which is at least partially operative by a decreased suppressor T cell activity. During infection, peripheral blood natural killer cell activity is decreased, but normalizes under anti-microbial therapy. Non-major histocompatibility complex-restricted lymphocytotoxicity to isolated heart cells can be present in one third of patients. Circulating immune complexes normalize during therapy. They may be the cause of many clinical symptoms of infective endocarditis. Anti-bacterial and also anti-sarcolemmal antibodies which are crossreactive to the bacterium are secreted in a polyclonal immune response. Anti-sarcolemmal antibodies which are cytolytic in vitro in the presence of complement may partly explain the myocardial factor of heart failure in patients with only marginal valve incompetence due to the endocarditic vegetation.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Autoreactive mechanisms in infective endocarditis

Maisch

1989

Springer Semin Immunopathol

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“…Surgery and extracorporeal circulation duration, in contrast with the data from Maisch 17 was not associated with the event, which may be justified by the development of greater intraoperative myocardial protection techniques, including cardioplegia and of new anesthetics.…”

Section: Discussionmentioning

confidence: 87%

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

Köhler¹,

Saraiva²,

Wender³

et al. 2003

Arq. Bras. Cardiol.

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OBJECTIVE: To verify the association of serum markers of myocardial injury, such as troponin I, creatinine kinase, and creatinine kinase isoenzyme MB, and inflammatory markers, such as tumor necrosis factor alpha (TNF-alpha), C-reactive protein, and the erythrocyte sedimentation rate in the perioperative period of cardiac surgery, with the occurrence of possible postpericardiotomy syndrome. METHODS: This was a cohort study with 96 patients undergoing cardiac surgery assessed at the following 4 different time periods: the day before surgery (D0); the 3rd postoperative day (D3); between the 7th and 10th postoperative days (D7-10); and the 30th postoperative day (D30). During each period, we evaluated demographic variables (sex and age), surgical variables (type and duration , extracorporeal circulation), and serum dosages of the markers of myocardial injury and inflammatory response. RESULTS: Of all patients, 12 (12.5%) met the clinical criteria for a diagnosis of postpericardiotomy syndrome, and their mean age was 10.3 years lower than the age of the others (P=0.02). The results of the serum markers for tissue injury and inflammatory response were not significantly different between the 2 assessed groups. No significant difference existed regarding either surgery duration or extracorporeal circulation. CONCLUSION: The patients who met the clinical criteria for postpericardiotomy syndrome were significantly younger than the others were. Serum markers for tissue injury and inflammatory response were not different in the clinically affected group, and did not correlate with the different types and duration of surgery or with extracorporeal circulation

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Zur Immunpathogenese perimyokardialer Erkrankungen

Cited by 2 publications

References 102 publications

Autoreactive mechanisms in infective endocarditis

Autoreactive mechanisms in infective endocarditis

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

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