Zur histochemie der xanthin-dehydrogenase

Wohlrab, F; Seidler, E

doi:10.1016/s0065-1281(78)80111-1

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…The authors reported the expression of XOR in the vascular component of the intestinal wall and suggested that the enzyme may be a specific marker for the endothelium. The data reported here are substantially at variance with the observations in the bovine model [32], which may be explained by the different technology used (immunocytochemistry compared with in situ hybridization) or, more likely, species-specific differences. Nevertheless, except in heart and possibly lung, our results clearly do not support the idea that XOR is specifically localized in the vascular component of the various tissues and organs.…”

Section: Determination Of Xor-positive Cells By In Situ Hybridizationcontrasting

confidence: 73%

“…In the past, localization of XOR at the single-cell level has not been the object of a systematic study, although scattered observations in the intestine, liver and mammary gland have been reported in a few animal species [29][30][31][32]. These data were, however, generated by cytochemical techniques which generally lack specificity and, moreover, gave contrasting results.…”

Section: Determination Of Xor-positive Cells By In Situ Hybridizationmentioning

confidence: 99%

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Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide

Kurosaki

Calzi

Scanziani

et al. 1995

Biochemical Journal

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The expression of the xanthine oxidoreductase gene was studied in various mouse organs and tissues, under basal conditions and on treatment with bacterial lipopolysaccharide. Levels of xanthine oxidoreductase protein and mRNA were compared in order to understand the molecular mechanisms regulating the expression of this enzyme system. The highest amounts of xanthine oxidoreductase and the respective mRNA are observed in the duodenum and jejunum, where the protein is present in an unusual form because of a specific proteolytic cleavage of the primary translation product present in all locations. Under basal conditions, multiple tissue-specific mechanisms of xanthine oxidoreductase regulation are evident. Lipopolysaccharide increases enzyme activity in some, but not all tissues, mainly via modulation of the respective transcript, although translational and post-translational mechanisms are also active. In situ hybridization studies on tissue sections obtained from mice under control conditions or with lipopolysaccharide treatment demonstrate that xanthine oxidoreductase is present in hepatocytes, predominantly in the proximal tubules of the kidney, epithelial layer of the gastrointestinal mucosa, the alveolar compartment of the lung, the pulpar region of the spleen and the vascular component of the heart.

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Section: Determination Of Xor-positive Cells By In Situ Hybridizationcontrasting

confidence: 73%

Section: Determination Of Xor-positive Cells By In Situ Hybridizationmentioning

confidence: 99%

Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide

Kurosaki

Calzi

Scanziani

et al. 1995

Biochemical Journal

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A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase

Kooij

1994

Histochem J

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Xanthine oxidoreductase is an enzyme which has the unusual property that it can exist in a dehydrogenase form which uses NAD+ and an oxidase form which uses oxygen as electron acceptor. Both forms have a high affinity for hypoxanthine and xanthine as substrates. In addition, conversion of one form to the other may occur under different conditions. The exact function of the enzyme is still unknown but it seems to play a role in purine catabolism, detoxification of xenobiotics and antioxidant capacity by producing urate. The oxidase form produces reactive oxygen species and, therefore, the enzyme is thought to be involved in various pathological processes such as tissue injury due to ischaemia followed by reperfusion, but its role is still a matter of debate. The present review summarizes information that has become available about the enzyme. Interpretations of contradictory findings are presented in order to reduce confusion that still exists with respect to the role of this enzyme in physiology and pathology.

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A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase

Kooij

1994

Histochem J

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Zur histochemie der xanthin-dehydrogenase

Cited by 6 publications

References 18 publications

Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide

Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide

A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase

A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase

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