Zur Heterogenie der Progenie

Interrelation between Occlusal Findings and Orofacial Myofunctional Status in Primary and Mixed Dentition

“…Their theories are no longer disputed -they form the basis of functional orthodontic therapy [15]. We have known since Schulze [33,34] that all anomalies regarding the position of teeth and jaw malrelationships originate in the genotype. The latter determines the influence exerted by exterior factors, whether they have a positive or negative effect on the phenotype.…”

“…Diese seit Langem unbestrittenen Zusammenhänge sind letztlich die Basis für die kieferorthopädische Einflussnahme [15]. Seit Schulze [33,34] ist bekannt, dass alle menschlichen Zahnstellungs-und Bisslageanomalien im Genotypus verankert sind. Dieser bestimmt, welchen Einfluss äußere Faktoren besitzen, ob sie abschwächend oder verstärkend den Phänotypus gestalten.…”

Review of the Genetic Basis of Jaw Malformations

“…18 Concordance of malocclusion was six times higher in monozygotic twins than in dizygotic twins. 19 Based on lateral cephalometry data, Watnick further hypothesized that certain areas of the mandible were under greater genetic control, including the lateral ramus and lingual symphysis. 20 Other areas by reasoning, such as the antegonial notch, were therefore under predominantly environmental control.…”

Epidemiology of Hoffmeister?s Genetically Determined Predisposition to Disturbed Development of the Dentition in Patients with True Skeletal Class III Malocclusion

“…Patients with clefts of lip, alveolus and palate, patients with syndromes and family members of the subjects were excluded from the study. [46] fand in Sippenuntersuchungen einen genetischen Zusammenhang zwischen der Hypodontie und der Progenie und beschrieb die Kombination von Zahnverformungen, Mikrodontie, Hypodontie und Progenie [47]. Andere Mikrosymptome wie der vergrößerte Molarenkeimabstand im Unterkiefer, der verfrühte Wechsel der Dentition im Oberkiefer und die atypische Keimlage, insbesondere die der Frontzähne, wurden bereits von Hotz [26], Thompson [58] und Schulze [48] beschrieben.…”

“…But they found no significant difference regarding dental eruption between Class II and Class III patients. Schulze [46] saw a genetical context between hypodontia and true mandibular prognathism in his genealogical studies and described the combination of dental malformations, microdontia, hypodontia and skeletal Class III malocclusion [47]. Other microsymptoms such as increased distance between molar buds in the mandible, accelerated eruption of permanent upper teeth, and atypical location of tooth buds -especially of the anterior teeth -were described by Hotz [26], Thompson [58], and Schulze [48].…”