Zur Häufigkeit der exzessiven Verdickung der epithelialen Basalmembran beim Keratokonus

Jm, Rohrbach; Szurman, Peter; El-Wardani, M; Grüb, Matthias

doi:10.1055/s-2006-927096

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…Teng (1963) even postulated that the origin of this disease was to be found in the epithelium, 20 and this hypothesis has later received further scientific support. 6,7,12,21–23 …”

mentioning

confidence: 99%

“…However, with few exceptions, they lack morphometry and in some cases, are limited to light microscopy and a protocol using a high osmolality fixative that further distorts an already distorted cornea. 12,23,28–30 The purpose of this study was to systematically investigate and quantify pertinent histopathological changes in a series of Kc corneas, at both the apex of the cone and the adjacent mid-peripheral corneal region, using an established fixative with physiological osmolality.…”

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confidence: 99%

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Quantified Histopathology of the Keratoconic Cornea

Mathew¹,

Goosey²,

Bergmanson

2011

Optometry and Vision Science

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Purpose The present study systematically investigated and quantified histopathological changes in a series of keratoconic (Kc) corneas utilizing a physiologically formulated fixative to not further distort the already distorted diseased corneas. Methods Twelve surgically removed Kc corneal buttons were immediately preserved and processed for light and transmission electron microscopy using an established corneal protocol. Measurements were taken from the central cone and peripheral regions of the host button. The sample size examined ranged in length from 390–2608um centrally and 439–2242um peripherally. Results The average corneal thickness was 437um centrally and 559um peripherally. Epithelial thickness varied centrally from 14–92um and peripherally from 30–91um. A marked thickening of the epithelial basement membrane was noted in 58% of corneas. Centrally, anterior limiting lamina (ALL) was thinned or lost over 60% of the area examined, while peripheral cornea was also affected, but to a lesser extent. Histopathologically, posterior cornea remained undisturbed by the disease. Anteriorly in the stroma, an increased number of cells and tissue debris were encountered and some of these cells were clearly not keratocytes. Conclusions It is concluded that Kc pathology, at least initially, has a distinct anterior focus involving the epithelium, ALL and anterior stroma. The epithelium had lost its cellular uniformity and was compromised by the loss or damage to the ALL. The activity of the hitherto unreported recruited stromal cells may be to break down and remove ALL and anterior stromal lamellae leading to the overall thinning that accompanies this disease.

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“…Teng (1963) even postulated that the origin of this disease was to be found in the epithelium, 20 and this hypothesis has later received further scientific support. 6,7,12,21–23 …”

mentioning

confidence: 99%

mentioning

confidence: 99%

Quantified Histopathology of the Keratoconic Cornea

Mathew¹,

Goosey²,

Bergmanson

2011

Optometry and Vision Science

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“…However, around this area (and with marked stromal thinning), epithelial thickening may occur; this is referred to as the donut pattern [11,12]. A thickening of the epithelial basal membrane is sometimes also described with keratoconus [13]. As in corneal ulcers, the loss of stromal material/stromal thinning can be compensated by thickening of the epithelium (▶ Fig.…”

Section: Keratoconusmentioning

confidence: 99%

Histopathologische Veränderungen bei kornealen Ektasien

Bulirsch

Löffler

Holz

et al. 2023

Klin Monbl Augenheilkd

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Den kornealen Ektasien werden der Keratokonus, der Keratoglobus, die pelluzide marginale Degeneration sowie iatrogene Keratektasien zugeordnet. Bei allen Formen der kornealen Ektasie kommt es zu einer Verdünnung der Hornhaut, die mit einer kornealen Aufsteilung sowie einem irregulären Astigmatismus einhergeht. Nachfolgend wird ein Überblick über histopathologische Veränderungen der verschiedenen kornealen Ektasien gegeben. Ebenso werden histologische Veränderungen nach operativen Verfahren, die im Zusammenhang mit Ektasien durchgeführt werden, wie das korneale Crosslinking und die perforierende Keratoplastik (pKPL) sowie nach refraktiven chirurgischen Verfahren, die potenziell zu einer Ektasie führen können, dargestellt. Neben einer Literaturrecherche erfolgte auch die Aufarbeitung und Untersuchung von histopathologischem Archivmaterial zur exemplarischen Darstellung der spezifischen histologischen Veränderungen. Corneal ectasia comprises keratoconus, keratoglobus, pellucid marginal degeneration, and iatrogenic keratectasia. In all forms of corneal ectasia, there is a thinning of the cornea, usually accompanied by steepening of the cornea, leading to irregular astigmatism. Here we provide an overview of histopathologic alterations of the various corneal ectasias. Furthermore, histologic changes after surgical procedures which are performed in severe cases of corneal ectasia such as corneal crosslinking and penetrating keratoplasty (pKPL) as well as refractive surgical procedures which may lead to postsurgical ectasia are presented. In addition to a literature review, histopathologic archival material was reviewed and examined to illustrate the specific histologic changes.

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“…Чаще всего первые признаки КК проявляются у подростков в возрасте 15-18 лет, но патологический процесс может начинаться и в более позднем возрасте. Многочисленность приводимых в литературе факторов, способствующих возникновению КК, не позволяет в настоящее время говорить о четко обоснованной этиологии этого заболевания [2,[6][7][8].…”

Section: To Cite This Articleunclassified

Modern options for non-surgical correction of keratoconus

Myagkov¹,

Каролина

Mitichkina³

et al. 2020

Vestn. oftal'mol.

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РЕЗЮМЕ В обзоре представлены данные о так называемых нехирургических методах коррекции кератоконуса (КК). Комплексный подход к корригирующему воздействию на это заболевание роговицы предполагает решение трех основных задач: профилактику прогрессирования, оптическую коррекцию индуцированных рефракционных нарушений и восстановление структурных изменений. Решение первых двух следует расценивать как симптоматическое, а последней-патогенетически ориенти рованное. Кросслинкинг коллагена роговицы и оптическую коррекцию рефракционных нарушений с помощью жестких газопроницаемых склеральных контактных линз следует рассматривать в качестве «нехирургических» методов первого выбора симптоматической коррекции кератоконуса. Ключевые слова: кератоконус, кросслинкинг роговичного коллагена, жесткие газопроницаемые склеральные контактные линзы.

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Zur Häufigkeit der exzessiven Verdickung der epithelialen Basalmembran beim Keratokonus

Abstract: A massively thickened epithelial BM can be occasionally observed in KC but is rare on the whole. It is most likely an unspecific secondary phenomenon and not a prerequisite for KC development. The "inverse cornea guttata" was a unique finding.

Cited by 8 publications

References 18 publications

Quantified Histopathology of the Keratoconic Cornea

Quantified Histopathology of the Keratoconic Cornea

Histopathologische Veränderungen bei kornealen Ektasien

Modern options for non-surgical correction of keratoconus

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