Zur Funktion des β3-Adrenozeptors am Herzen: Signaltransduktion, inotroper Effekt und therapeutischer Ausblick

Pott, Christian; Steinritz, Dirk; Napp, Andreas; Bloch, Wilhelm; Schwinger, Robert H. G.; Brixius, Klara

doi:10.1007/s10354-006-0273-x

Cited by 7 publications

(2 citation statements)

References 62 publications

(93 reference statements)

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“…An imbalance of subnormal cardiac parasympathetic regulation coupled with elevated cardiac sympathetic activation is involved in many cardiovascular diseases including AF, while enhanced cardiac parasympathetic regulation is associated with restoration of β-AR balance and protection of AF induced by acute myocardial ischemia [7]. It has been recognized that at least three different adrenoceptor subtypes, β 1 -, β 2 -and β 3 -adrenoceptors (β-ARs), participated in the regulation of cardiac function and electrical activity [8][9][10]. β 3 -AR differs from β 1 -and β 2 -AR subtypes in its molecular structure and pharmacological functions [11].…”

Section: Introductionmentioning

confidence: 99%

Activation of β<sub>3</sub>-Adrenoceptor Promotes Rapid Pacing-Induced Atrial Electrical Remodeling in Rabbits

et al. 2011

Cell Physiol Biochem

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Cardiac electrophysiological function is under the regulatory control of the sympathetic nervous system. In addition to classical β-adrenoceptors (β-AR, including β₁- and β₂- subtypes), β₃-AR is also expressed in human heart and shows its distinctive functions. This study is aimed to elucidate the role of β₃-AR in the regulation of atrial fibrillation (AF), especially its role in rapid pacing-induced atrial electrical remodeling in rabbits. The rapid atrial pacing model was established by embedding electrodes in the right atrium pacing at a speed of 600 beats per minute. The protein level of β₃-AR in the atria was found significantly upregulated by western blot. The atrial effective refractory period (AERP) and its rate adaptation were decreased after pacing which were further shortened by BRL37344, a selective β₃-AR agonist, leading to the increase of AF inducibility and duration. Similarly, β₃-AR activation induced time-dependent shortening of action potential duration (APD), together with decrease of L-type calcium current (I_Ca,L) and increase of inward rectifier potassium current (I_K1) and transient outward potassium current (I_to) in rapid pacing atrial myocytes. Meanwhile, all the effects were abolished by specific β₃-AR antagonist, SR59230A. In summary, our study represents that activation of β₃-AR promotes the atrial electrical remodeling process by altering the balance of ion channels in atrial myocytes, which provides new insights into the pharmacological role of β₃-AR in heart diseases.

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Section: Introductionmentioning

confidence: 99%

Activation of β<sub>3</sub>-Adrenoceptor Promotes Rapid Pacing-Induced Atrial Electrical Remodeling in Rabbits

et al. 2011

Cell Physiol Biochem

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“…В то же время мы не исключаем, что удельная сила сокращений левого желудочка сердца, в том числе у крысы, при беременности может возрастать, чтобы обеспечить более эффективное снабжение плода кислородом и питательными веществами. Следует отметить, что согласно данным работы [38], у крыс при беременности возрастает синтез оксида азота в левом желудочке, который, по данным литературы [39,40], снижает сократимость миокарда. Все это подтверждает наш вывод о том, что при беременности удельная сила сокращений как отражение сократимости миокарда не возрастает.…”

Section: результаты исследования и их обсуждениеunclassified

Contractility and electroexcitability of isolated myocardium of right ventricular of rat heart depending on estrous cycle and pregnancy

Korotaeva

Nozdrachev

Tsyrkin

2015

BioComm

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It is known that women and rats have increased minute volume of blood flow (MV) during pregnancy. It is believed that this is due to an increase in heart rate. This remains unclear — whether pregnancy increases myocardial contractility (and consequently increases the stroke volume). There are no data on changes of myocardium electroexcitability during pregnancy. To clarify these issues, experiments were conducted on strips of right ventricular of 94 nonpregnant and 45 pregnant rats. The strips were perfused with Krebs solution at 37 °C, which is preenriched by pure oxygen, and after 30 minutes of adaptation evaluated force of contractions. They are caused by electrostimulation (5 ms, 1 Hz, 20 V) applied transmural. Then determined the excitation threshold, i.e, minimum voltage (V), wherein a single stimul (5 ms) induced contraction. It was found that the force of contraction (mN, mN/mg wet weight or mN/mg dry weight of strips ) and the excitation threshold do not depend on the phase of the estrous cycle, pregnancy, and the availability of its terms. This means that during pregnancy contractility of right ventricle of rats myocardial does not change, and even tends to decrease. Therefore, increasing of MV during pregnancy, most likely due to an increase in heart rate. It was also established that at the end of pregnancy water content increases (on 12 %) in the myocardium (perhaps by increasing the expression of aquaporins in cardiomyocytes) which is regarded as a reflection of adaptation. Refs 41. Figs 4.

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Pulmonary Hypertension: Old Targets Revisited (Statins, PPARs, Beta-Blockers)

Watson

Oliver

Zhao

et al. 2013

Handbook of Experimental Pharmacology

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Pulmonary arterial hypertension is a therapeutic challenge. Despite progress in recent years with three drug classes-prostanoids, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors-long-term patient survival remains poor. Importantly, the introduction and commercial success of these new treatments has been accompanied by growing interest in the pathology of pulmonary hypertension. This, in turn, has stimulated a re-evaluation of the molecular factors driving the structural remodelling of pulmonary arterioles and the opportunities to preserve right ventricular function in pulmonary hypertension. Academics with restricted access to new chemicals have turned to existing drugs to investigate new ideas. It is in this context that the role of statins, peroxisome proliferator-activated receptors (PPARs) and beta-blockers are of interest as potential treatments for pulmonary hypertension.

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Zur Funktion des β3-Adrenozeptors am Herzen: Signaltransduktion, inotroper Effekt und therapeutischer Ausblick

Cited by 7 publications

References 62 publications

Activation of β<sub>3</sub>-Adrenoceptor Promotes Rapid Pacing-Induced Atrial Electrical Remodeling in Rabbits

Activation of β<sub>3</sub>-Adrenoceptor Promotes Rapid Pacing-Induced Atrial Electrical Remodeling in Rabbits

Contractility and electroexcitability of isolated myocardium of right ventricular of rat heart depending on estrous cycle and pregnancy

Pulmonary Hypertension: Old Targets Revisited (Statins, PPARs, Beta-Blockers)

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