“…Still another suggestion advanced is that the products of the infection, such as toxins or trypsin (produced from pus or leucocytes), actually destroy or inactivate insulin [cf. Minkowski, 1926; Rosenthal and Behrendt, 1926;Karelitz, Cohen and Le.ader, 1930]. Although it is possible to demonstrate this inactivation in vitro, it is by no means certain that the same occurs in the body.…”