Zur Frage der Schilddrüsenfunktion bei Adipositas

Scriba, Peter Christian; Richter, J.; Horn, K.; Beckebans, J.; Schwarz, K.

doi:10.1007/bf01747113

Cited by 11 publications

(2 citation statements)

References 15 publications

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“…2 (Scriba et al 1967) than in healthy normal weight controls (P < 0.001). 2 (Scriba et al 1967) than in healthy normal weight controls (P < 0.001).…”

Section: Thyroxine (T4)mentioning

confidence: 78%

“…3,5,3'-L-triiodothyronine (To) levels in serum were shown to decrease during fasting whereas the metabolically inactive metabolite of thyroxine 3,3',5'-L-triiodothyronine (reverse T3, rT3) increased (Balsam 8c Ingbar 1977*; Carlson et al 1977;Croxson et al 1977;Mérimée 8c Fineberg 1976;Palmblad et al 1977;Portnay et al 1974;Vagenakis et al 1975Vagenakis et al , 1977 while total thyroxine (T4) levels remained constant. This study was performed in order to evaluate the possibility that the changes in BMR could be due to thyroid hormone deficiency arising from fasting (Hofmann et al 1974: Scriba et al 1967Scriba 8c Hof¬ mann 1976). This study was performed in order to evaluate the possibility that the changes in BMR could be due to thyroid hormone deficiency arising from fasting (Hofmann et al 1974: Scriba et al 1967Scriba 8c Hof¬ mann 1976).…”

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confidence: 99%

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EFFECTS OF OBESITY, TOTAL FASTING AND RE-ALIMENTATION ON l-THYROXINE (T4), 3,5,3'-l-TRIIODOTHYRONINE (T3), 3,3',5'-l-TRIIODOTHYRONINE (rT3), THYROXINE BINDING GLOBULIN (TBG), CORTISOL, THYROTROPHIN, CORTISOL BINDING GLOBULIN (CBG), TRANSFERRIN, α2-HAPTOGLOBIN AND COMPLEMENT C'3 IN SERUM

Scriba

Bauer

Emmert

et al. 1979

Acta Endocrinologica

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The effects of total fasting for 31 ± 10 days followed by re-alimentation with an 800 calorie diet on thyroid function, i.e. T4,T3, rT3, RT3U (resin T3 uptake), and TSH, and on TBG levels in serum were studied sequentially in obese hospitalized patients (N = 18). Additionally, cortisol, growth hormone, prolactin, parathyrin and free fatty acids were followed as hormonal and metabolic parameters, respectively. Further, CBG, transferrin, α2-haptoglobin and complement C'3 were measured as representatives of other serum proteins. Results before fasting: T4, T3,3, TBG, cortisol, CBG, α2-haptoglobin and complement C'3 of the obese patients were elevated when compared with healthy normal weight controls, whereas rT3, T4/TBG ratio, T3/TBG ratio, TSH, cortisol/CBG ratio, growth hormone, prolactin, parathyrin and transferrin of the obese group were normal. RT3U and fT4 index were decreased in the obese patients. Results during fasting: Significant decreases were observed during fasting for the following parameters – T3, TBG, T3/TBG ratio, transferrin, α2-haptoglobin, complement C'3. rT3, T4/TBG ratio, RT3U, fT4 index and FFA increased. T4, TSH response to TRH stimulation, cortisol, CBG, cortisol/CBG ratio, parathyrin, growth hormone and prolactin did not change. Results during re-alimentation: T3, TBG, T3/TBG ratio, TSH response to TRH, transferrin, α2-haptoglobin and complement C'3 increased. Conversely, rT3, RT3U, FFA, cortisol and cortisol/CBG ratio decreased, whereas the other parameters did not change. Conclusions: 1) There is no evidence for primary hypothyroidism in obese patients during prolonged fasting and re-alimentation. 2) The rapid decrease of T3 and increase of RT3U after initiation of fasting are not fully explained by the observed slower decreases in TBG. 3) The alterations of T3, rT3 and RT3U resemble in their kinetics the changes in FFA levels. 4) Fasting reduced the levels of only certain serum proteins, interestingly TBG, transferrin, α2-haptoglobin and complement C'3, all of which, except transferrin, are elevated in obesity. 5) The magnitude of the observed decreases does not suggest any clinically relevant deficiencies in serum proteins. 6) Re-alimentation reverses rapidly all observed changes.

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“…2 (Scriba et al 1967) than in healthy normal weight controls (P < 0.001). 2 (Scriba et al 1967) than in healthy normal weight controls (P < 0.001).…”

Section: Thyroxine (T4)mentioning

confidence: 78%

mentioning

confidence: 99%