Zur Frage der perinatalen Hepatitis B-Virus-Infektion durch HBS-Ag-Träger-Mütter

Review article

“…Not all these HB s Ag carrier mothers are also HB e Ag positive, REESINK found 25% HB e Ag positive carrier mothers with sensitive RIA method [38]. The same figure was found by MÜLLER in Hannover [34],…”

“…Sie manifestiert sich in einer chronischen, symptomlosen HB s Antigenämie, einer klinischen Hepatitis-B und sogar in einer fulminant verlaufenden, akuten Hepatitis B [22,23]. Auch sind mehrere Fälle von HB s -Antigenämie und akuter Hepatitis B im Säuglingsalter beschrieben worden, wobei die Mütter HB s Ag-positiv und anti-HB e -positiv waren [20,33,34,43]. Nur bei einer anti-HB s -positiven Mutter besteht keine Infektionsgefahr mehr, da diese Antikörper plazentagängig sind.…”

“…It is generally accepted that HB s Ag and HB e Ag positive mothers do infect their children in almost 90-100% [5,35]. MÜLLER found an incidence of 25% HB s Ag infection in children born to chronic asymptomatic HB s Ag carrier-mothers [34]. Its generally assumed that newbom children will escape infection [5], when the mother is HB s Ag positive and anti-HB e positive.…”

“…20% des hepatites sont provoques par le virus A. L'hepatite A est une maladie de duree limitee qui produit une immunite persistente mais qui ne devient jamais chronique [31]. Le virus de l'hepatite A n'est pas teratogene et une infection par ce virus pendant les 2 Premiers mois de la gross-esse n'est pas une indication d'avortement [11,16] [20,33,34,43]. Seules les meres qui sont positives pour les anticorps HB S ne peuvent pas infecter leurs enfants, parce que ces anticorps passent la barriere placentaire.…”

“…The virus hepatitis is not particularly lethal to the pregnant women, except in areas where protein malnutrition is frequent [42]. Since the detection of the hepatitis A virus (HAV), the discovery of the hepatitis B surface antigen (HB s Ag) and its association with hepatitis B virus (HBV) infection, hepatitis A and B have become distinguishable by specific serological tests [7,8,14,34]. Recent advantage in the study of hepatitis A virus (HAV), including its cultivation and production of a vaccin, made diagnosis by means of the RIA kit for HAV-antibodies (anti-HAV) much easier.…”