Zur Frage der Herkunft der Makrophagen nach Kälteeinwirkung auf die menschliche Netzhaut

Lerche, W.

doi:10.1159/000306765

Cited by 8 publications

(4 citation statements)

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“…Furthermore, the evaluation of the results was difficult as the lesions were invaded by inflammatory cells from the choroitl or the retinal vessels (Gloor 1969;Machemer tk Laqua 1955). and cells werc found in Bruch's membrane (Lerche 1972).…”

Section: The Process Of Wound Healing Of the Retinal Lesionsmentioning

confidence: 77%

“…the possible process of amitotic proliferation was not followed. T h e possible origin of migrating phagocytic cells from the pigment epithelium is suggested by morphological similarity of the pigment epithelial cells and the phagocytic cells found in retinal lesions produced by Xenon arc photocoagulation of rabbit eyes (Gloor 1969), by cryotherapy of human eyes (Lerche 1972), and by retinal detachment in monkey eyes (Machemer k Idaqua 197.5). Based on the observations of pigment epithelial cells with apically placed nuclei, and pigment epithelial cells with mitotic figures a t the periphery of the lesions in rabbits treated with colchicin before fixation, (;loor ( 1 9fi9) suggested two possibilities: (1) that phagocytic cells may originate from the pigment epithelial cells with apically placed nuclei which were considered t o detach from Bruch's membrane, or (2) that phagocytic cells may originate from proliferating pigment epithelial cells.…”

Section: The Process Of Wound Healing Of the Retinal Lesionsmentioning

confidence: 99%

“…Based on the observations of pigment epithelial cells with apically placed nuclei, and pigment epithelial cells with mitotic figures a t the periphery of the lesions in rabbits treated with colchicin before fixation, (;loor ( 1 9fi9) suggested two possibilities: (1) that phagocytic cells may originate from the pigment epithelial cells with apically placed nuclei which were considered t o detach from Bruch's membrane, or (2) that phagocytic cells may originate from proliferating pigment epithelial cells. 'These two possibilities could not be evaluated by Lerche (1972) as only 7 and 12 day old lesions were studied. nor by Machemer k Laqua (1975) as many detached cells were found in the primary lesions.…”

Section: The Process Of Wound Healing Of the Retinal Lesionsmentioning

confidence: 99%

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The Process of Wound Healing of the Avascular Outer Layers of the Retina

Bülow

1978

Acta Ophthalmologica

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The process of wound healing of the avascular outer layers of the retina is studied on a series of Laser lcsions of the monkey, Ccrc.oliitl/fr.ilt;~~~~.~ uelhio/).s. T h e extent of the retinal lesions is limited to thc pigment epithelium and photoreceptor cells, whereas Bruch's membrane anti the vascular inner layers of the retina remain intact. The retinal lesions arc not seen to be invaded by cells from the chortiid. nor from the retinal vessels. During the first three days after irradiation the pigment epithelial cells in a zone, about 7 5 pin wide. around the lesions appear to be changcd into bi-or multinucleate cells with thc additional nuclei situated in apical cytoplasmic protrusions which extend towards and into the lesions. During the second and third days after irradiation the lesions arc invaded by two kinds of cells which both appear to arise through the off-budding of the nucleus-containing apical protrusions of the pigment epithelial cells around the lesions: (a) phagocytic cells which disintegrate the damaged tissue and, as this process is completed 4-9 days after irradiation show cvitlence of melanogcncsis; and (b) regenerated pigment epithelium which forin a single lnycr of rells along Bruch's membrane, but show no evidc nce of phagocytosis or intracellular disintegration of the damaged tissue. Within the lesions both these kinds of cells show mitotic figures the third clay after irratliation.

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Section: The Process Of Wound Healing Of the Retinal Lesionsmentioning

confidence: 77%

Section: The Process Of Wound Healing Of the Retinal Lesionsmentioning

confidence: 99%

Section: The Process Of Wound Healing Of the Retinal Lesionsmentioning

confidence: 99%

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The Process of Wound Healing of the Avascular Outer Layers of the Retina

Bülow

1978

Acta Ophthalmologica

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“…Im Bereich des hinte ren Pols enthält diese Membran normaler weise keine Zellen H ogan und A lvarado, 1967;Lerche, 1972a;Spitznas, 1974], Nur bei pathologischen Ver änderungen nach Kryokoagulation oder La serstrahleinwirkung sind solche nachweisbar [Lerche, 1972b[Lerche, , 1973 …”

Section: Diskussionunclassified

Elektronenmikroskopische Untersuchungen über den Aufbau des Pigmentepithels an der Ora serrata

Lerche¹,

Kaune²

1980

Ophthalmologica

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The structure of the pigment epithelium at the ora serrata is examined in 10 human eyes aged from 31 to 90 years. The cells of the pigment epithelium show a different construction depending on their position relative to the ora. Directly at the ora serrata, in the cohesion band, the cells are higher and contain more pigment granula than those which are situated in a central region. In this sector we sometimes find overlapping of cells, which feigns two layers of epithelium. There are clearly fewer basal folding ins of the pigment epithelial cells at the ora than in the other parts of the retina. At the ora serrata pathological changes start in the 3rd decade of life. They include swelling and later on more or less pronounced cystoid degeneration of the epithelial cells. Within Bruch’s membrane two kinds of cells are seen. In the ora gap six types of free cells can be distinguished, whose origin is discussed especially. Probably they originate from the chorioidea, the pigment epithelium and the sensory retina.

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