Zur Frage der Beteiligung des Anaphylatoxins im anaphylaktischen Schock

Giertz, H.; Hahn, F.; Jurna, I.; Lange, A.

doi:10.1159/000228483

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1959

1978

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Cited by 14 publications

(4 citation statements)

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“…We particularly rejected the idea of AT formation in anaphylactic shock since we did not find a decrease of AT precursors [G iertz, H ahn, J urna and Lange, 1958].…”

Section: Discussionmentioning

confidence: 63%

Anaphylatoxin Tachyphylaxis and Anaphylaxis

Hahn¹,

Ebner²,

Giertz³

1969

Int Arch Allergy Immunol

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“…We particularly rejected the idea of AT formation in anaphylactic shock since we did not find a decrease of AT precursors [G iertz, H ahn, J urna and Lange, 1958].…”

Section: Discussionmentioning

confidence: 63%

Anaphylatoxin Tachyphylaxis and Anaphylaxis

Hahn¹,

Ebner²,

Giertz³

1969

Int Arch Allergy Immunol

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“…The studies reported by Giertz et al indicate that anaphylatoxin may only mediate the cytotoxic type of reaction (79). This conclusion is based on experiments with hepaHn which has been found in this laboratory to inactivate Cr3 but only to a limited extent, depending on factors such as discussed previously.…”

Section: Discussionmentioning

confidence: 63%

Studies on the Mechanism of Hypersensitivity Phenomena

Osler

Randall

Hill

et al. 1959

The Journal of Experimental Medicine

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The interaction of fresh rat and guinea pig serum with washed preformed immune aggregates has been studied with respect to the loss in hemolytic potency of the serum, diminution of the C'3; activity, and appearance of anaphylatoxin. It has been found that the formation of anaphylatoxin, as judged by its effect on capillary permeability and smooth muscle contraction, is coincident with or subsequent to the fixation of all the known C' components. Less anaphylatoxin is formed by aggregates formed with excess antigen than those in equivalence ratio combination. C' fixation, as well as anaphylatoxin production, may be inhibited by chelation of the divalent cations, presumably by interfering with the fixation of C'1, C'4, and C'2. Phlorizin suppresses the utilization of C'3 in immune hemolysis, C' fixation by antigen-antibody aggregates, and the production of anaphylatoxin. The biological activities associated with the fixation of C' are not manifest unless C'3 participates in this process at 37°C. It is concluded that the formation of anaphylatoxin may be regarded as a product of C' fixation.

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“…A number of workers have reported a sharp decline of serum complement in some animals during isophil (Evidence reviewed in References 13,14,15) and heterophil (2)(3)(4)(5) anaphylaxis. Many studies, however, have been interpreted as inconclusive or as evidence against the participation of complement in anaphylactic reactions (6,16,17 and reviewed in References 13,14,15).…”

Section: Discussionmentioning

confidence: 99%