Zur experimentellen Therapie der Tumoren

Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential

“…Its asymmetric unit consists of half a molecule of anion and cation, because the centre of symmetry is identical to the position of the ruthenium atom. This is in contrast to those of 1 and 2, both of which contain one molecule of anion and cation and 0.75 (1) or two (2) additional acetone molecules. Moreover, the structure of 1 shows partial disorder in one of the indazole ligands as well as in the tetrabutylammonium counterion and the co-crystallized acetone molecule.…”

“…The isomeric mixture of 1-and 2-ethylindazole was separated by column chromatography (n-hexane-ethyl acetate 3 : 1), yielding pure 1-ethylindazole (L2) in 48% yield (1.19 g). 1 H NMR (DMSO-d 6 , 500.10 MHz): δ 1.40 (t, 3H, J = 7 Hz, -CH 3 ), 4.40 (q, 2 H, J = 7 Hz, N-CH 2 -), 7.13 (dd, 1H, J = 8 Hz, J = 8 Hz, Hind), 7.38 (dd, 1H, J = 8 Hz, J = 8 Hz, Hind), 7.65 (d, 1H, J = 8 Hz, Hind), 7.76 (d, 1H, J = 8 Hz, Hind), 8.06 (s, 1H, Hind) ppm.…”

“…Elemental analyses were performed by the Microanalytical Service of the Institute of Inorganic Chemistry of the University of Vienna and were carried out with a Perkin Elmer 2400 CHN Elemental Analyzer. 1 H-NMR spectra were recorded on a Bruker Avance III™ instrument at 25 °C and 500.10 MHz. ESI-MS measurements were carried out on a Bruker AmaZon SL ion trap spectrometer (Bruker Daltonics GmbH) and the resulting data files were processed using Bruker Compass 1.3 and DataAnalysis 4.0.…”

“…The first survey of the anticancer activity of ruthenium compounds was reported by Collier and Krauss in 1931 1 and, twenty years later, Dwyer and co-workers showed the first promising anticancer results of Ru(III) complexes. 2 However, it took further decades until ruthenium(III) coordination compounds came into research focus as anticancer agents, [3][4][5][6][7] but also in the treatment of Alzheimer's disease 8 or as nitric oxide scavengers under the conditions of septic shock etc.…”

Structure, substitution and hydrolysis of Bis(trifluorobenzoylacetonato-O,O′)dichloro titanium(IV): An experimental and computational study

“…The activity of a metal complex against cancer is primarily related to the nature of the ligands and their substitution stability [13]. Knowledge of the structure and properties of titanium (IV) complexes are thus of importance and may lead to the design of new compounds with specific applications.…”