Zur Experimentellen Syphilisforschung

Frei, W.

doi:10.1007/bf01709677

Cited by 7 publications

(1 citation statement)

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“…Finkelstein (3) found the Himalayan rabbit more susceptible to initial infection than other groups although he made no statement as to whether these latter represented mongrels or definite breeds. Working with a family of silver rabbits, Frei (4) noted that they developed a significantly higher generalized lesion rate than other types of rabbits, and concluded that they were constitutionally susceptible. More recently Frazier and Mu (5) came to a similar conclusion regarding the albino rabbit, after observing that this variety offered less resistance to syphilitic infection than did a brown variety.…”

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The Reaction of Standard Breeds of Rabbits to Experimental Syphilis

Rosahn

1933

Journal of Experimental Medicine

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For several years a colony of standard bred rabbits has been maintained by this laboratory as the basis for the study of problems in constitution. The foundation stock for the colony was built up from pedigreed and registered animals purchased in this country and abroad. The breeds represented were chosen mainly on the basis of physical conformation, and the stock includes a full range of contrasting types from the small Polish to the Giant Flemish, and the cobby Dutch to the racy Belgian. Representative color varieties and coat characters are also included?One of the purposes for which this colony was organized was to provide material of known quality for the study of relations between constitution and susceptibility to disease (1). As an approach to these problems, experiments were carried out with pure bred rabbits of various lines to determine, on the one hand, whether such differences as are represented by breed characters may be associated with distinctive differences in the reaction to disease-producing agents, and on the other, for the purpose of selecting the most suitable material for a more detailed study of any relations which might be found. The present report is concerned with observations on the response of different breeds of rabbits to one of the agents employed, namely, Tr. pallidum.From time to time there has appeared in the literature of experimental syphilis suggestions that resistance to infection may be related to the breed or color of the 1 For a description of American breeds and standards of perfection, the reader is referred to the Guide Book issued periodically by The American Rabbit and Cavy Breeders Association, Inc., 7408 Normal Avenue, Chicago, Ill. Breeds recognized in other countries vary somewhat from those in America, but the standards agree in most essential respects. 907 on

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