Zur Entwicklung des menschlichen Zwischenhirnes

Kahle, Werner

doi:10.1007/bf00242726

Cited by 31 publications

(8 citation statements)

References 8 publications

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“…It is difficult to relate our results to previous studies, because transverse sections through the diencephalic BP of human embryos are rarely reported in the literature. However, we found that a Nissl section illustrated by Kahle (1956) in his Figure 5b is comparable to our Figure 5 (the stage of mantle differentiation also seems similar, although the age given is more advanced). The structure of the FP, BP, and adjacent APtz observed in this photomicrograph strictly corroborates our observations in human embryos.…”

Section: Discussionsupporting

confidence: 88%

“…7 in Lenn et al, 1978; Müller and O'Rahilly, 1989, Müller and O'Rahilly, 1990; present data at stages 18 and 20), and is clearly bilayered and shows the marginal migratory stream at stages 20–23 (Lenn et al, 1978; present data). Sections illustrated by Kahle (1956, his Fig. 5b) and Müller and O'Rahilly (1989, their Fig.…”

Section: Discussionmentioning

confidence: 98%

“…In this conventional view, all the ventral midline structures found on top of the cephalic flexure, rostral to the isthmus and up to the mammillary region (including SN and VTA), are, explicitely or explicitly, median basal plate derivatives of the midbrain (see Müller and O'Rahilly, 1989, Müller and O'Rahilly, 1990). However, Gilbert (1935) and Kahle (1956), studying human embryos, postulated the existence of a diencephalic tegmentum ventral to pretectum, dorsal thalamus, and ventral thalamus, and continuous with or forming a part of the subthalamus; these authors did not distinguish separate FP and BP domains.…”

Section: Discussionmentioning

confidence: 99%

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Structure of longitudinal brain zones that provide the origin for the substantia nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions

2000

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In a previous work, mapping early tyrosine hydroxylase (TH) expressing primordia in human embryos, the tegmental origin of the substantia nigra (SN) and ventral tegmental area (VTA) was located across several neuromeric domains: prosomeres 1-3, midbrain, and isthmus (Puelles and Verney, [1998] J. Comp. Neurol. 394:283-308). The present study examines in detail the architecture of the neural wall along this tegmental continuum in 6-7 week human embryos, to better define the development of the SN and VTA. TH-immunoreactive (TH-IR) structures were mapped relative to longitudinal subdivisions (floor plate, basal plate, alar plate), as well as to radially superposed strata of the neural wall (periventricular, intermediate, and superficial strata). These morphologic entities were delineated at each relevant segmental level by using Nissl-stained sections and immunocytochemical mapping of calbindin, calretinin, and GABA in adjacent sagittal or frontal sections. A numerous and varied neuronal population originates in the floor plate area, and some of its derivatives become related through lateral tangential migration with other neuronal populations born in distinct medial and lateral portions of the basal plate and in a transition zone at the border with the alar plate. Some structural differences characterize each segmental domain within this common schema. The TH-IR neuroblasts arise predominantly within the ventricular zone of the floor plate and, more sparsely, within the adjacent medial part of the basal plate. They first migrate radially from the ventricular zone to the pia and then apparently move laterally and slightly rostralward, crossing the superficial stratum of the basal plate. Several GABA-IR cell populations are present in this region. One of them, which might represent the anlage of the SN pars reticulata, is generated in the lateral part of the basal plate.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Structure of longitudinal brain zones that provide the origin for the substantia nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions

2000

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“…They used cladistic (and hence phylogenetic) relationships to provide the basis for kinship orderings of the parameters of the descending supraspinal pathways. In ontogenetic studies of the human diencephalon, Kahle (1956) distinguished five longitudinal zones. 22.9.1 (Fig.…”

Section: Long Descending Tracts and Motor Behaviourmentioning

confidence: 99%

Mammals

Voogd¹,

Nieuwenhuys²,

Dongen³

et al. 1998

The Central Nervous System of Vertebrates

107

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“…In view of the fact that the telodiencephalic boundary line is at the preoptic sulcus (Miiller and O'Rahilly, 1988a), it is interesting to see that even in advanced stages, such as 19, no structural differences in the matrix pattern exist between the preoptic and the more rostral areas. As Kahle (1956) pointed out, "ohne Anderung geht die Matrix der oralen hypothalamischen Region in die Matrix des medialen Ganglienhiigels und des Septum pellucidum uber. "…”

Section: Parts Of the Brainmentioning

confidence: 99%

Computer ranking of the sequence of appearance of 40 features of the brain and related structures in staged human embryos during the seventh week of development

et al. 1988

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The sequence of events in the development of the brain in human embryos, already published for stages 8-17, is here continued for stages 18 and 19. With the aid of a computerized bubble-sort algorithm, 58 individual embryos were ranked in ascending order of the features present. The increasing structural complexity provided 40 new features in these two stages. The chief characteristics of stage 18 (approximately 44 postovulatory days) are rapidly growing basal nuclei; appearance of the extraventricular bulge of the cerebellum (flocculus), of the superior cerebellar peduncle, and of follicles in the epiphysis cerebri; and the presence of vomeronasal organ and ganglion, of the bucconasal membrane, and of isolated semicircular ducts. The main features of stage 19 (approximately 48 days) are the cochlear nuclei, the ganglion of the nervus terminalis, nuclei of the prosencephalic septum, the appearance of the subcommissural organ, the presence of villi in the choroid plexuses of the fourth and lateral ventricles, and the stria medullaris thalami.

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Zur Entwicklung des menschlichen Zwischenhirnes

Cited by 31 publications

References 8 publications

Structure of longitudinal brain zones that provide the origin for the substantia nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions

Structure of longitudinal brain zones that provide the origin for the substantia nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions

Mammals

Computer ranking of the sequence of appearance of 40 features of the brain and related structures in staged human embryos during the seventh week of development

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