Zur Debatte über Medienethik in Österreich

Langenbucher, Wolfgang R.

doi:10.1007/978-3-322-99816-3_4

Cited by 2 publications

(3 citation statements)

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“…Subsequently, the compound is given intravenously and plasma and CSF samples have to be collected. The BBB input profile can be obtained by a mathematical procedure called deconvolution [17,18]. Principally one can obtain information on passive and active transport processes in the brain.…”

Section: The Unit Impulse Response Proceduresmentioning

confidence: 99%

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In Vivo Methods to Estimate Drug Transport to the Brain Across the Blood-Brain Barrier

Boer¹,

Gaillard²

2005

MCRO

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In this paper, we review the in vivo methods to estimate drug transport to the brain. These vary from invasive ones like the brain uptake index (BUI), multiple pass techniques, brain efflux index (BEI), in situ brain perfusion, CSF (cerebrospinal fluid) sampling (unit impulse response), quantitative autoradiography (QAR), and intracerebral microdialysis to non invasive ones like positron emission tomography (PET), and magnetic resonance techniques (imaging (MRI), spectroscopy (MRS)). The latter two methods can be applied in human also. In addition, in this review an overview is given for which purposes these methods can be applied.

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Section: The Unit Impulse Response Proceduresmentioning

confidence: 99%

“…This procedure together with numerical deconvolution [16][17][18] has been applied (1989) to estimate BBB-and/or blood-CSF transport based on serial CSF sampling in the cisterna magna [19]. This procedure allows the construction of a complete time-transport profile in a single anaesthetized animal.…”

Section: The Unit Impulse Response Proceduresmentioning

confidence: 99%

In Vivo Methods to Estimate Drug Transport to the Brain Across the Blood-Brain Barrier

Boer¹,

Gaillard²

2005

MCRO

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“…31) Recently published in vivo plasma profiles following oral administration of paracetamol solution 32) were used as weighing function with dose normalization to compensate for the difference between the published data and the studied tablets.…”

Section: Sem Observationsmentioning

confidence: 99%

Application of Hot-Melt Coating Process for Designing a Lipid Based Controlled Release Drug Delivery System for Highly Aqueous Soluble Drugs

Knežević

Gosak

Hraste

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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Hot-melt coating process (HMCP) was applied to develop a lipid based oral controlled release matrix system (tablet) to deliver highly aqueous soluble drugs using paracetamol as a model drug. Granules prepared from paracetamol and particular filler were coated with different levels of lipid and then compressed into tablets to get controlled/sustained delivery of the drug over an optimum period. Process parameters were optimized with particular focus on fluidization pattern during HMCP proposing a 'design space' with 'Quality by Design' (QbD) concept in mind. The results demonstrated that the granule composition influenced the drug release pattern, and the rate of release could be manipulated by varying the amount of lipid in the formulation. The in vitro release profile of the drug was pH-independent and the most promising release profile was obtained from tablets prepared from granules with the water-soluble filler, lactose, and coated at 9% (w/w) level with a lipid, glyceryl behanate. In vivo plasma profiles of the drug were predicted from the in vitro release profile data by convolution analysis which confirmed that the lactose based formulation with 9% (w/w) lipid coating on the granules would be suitable for controlled delivery of the drug over a period of 12 h making the formulation suitable for highly water soluble drug candidates like paracetamol with twice daily dose regimen. Moreover, the dissolution data adequately fitted into Higuchi model suggesting that the drug release occurred predominantly by diffusion.

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Zur Debatte über Medienethik in Österreich

Cited by 2 publications

References 1 publication

In Vivo Methods to Estimate Drug Transport to the Brain Across the Blood-Brain Barrier

In Vivo Methods to Estimate Drug Transport to the Brain Across the Blood-Brain Barrier

Application of Hot-Melt Coating Process for Designing a Lipid Based Controlled Release Drug Delivery System for Highly Aqueous Soluble Drugs

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