Zur biosynthese des tryptophans in Saccharomyces cerevisiae II. Über die konstitution unbekannter akkumulate bei trp−-mutanten

Indole alkaloids from Balansia epichloe (Weese)

“…Preparative TLC in solvent systems I and II as described (cf. text) yielded 24 mg of 3-(3,3-diindolyl)propane-l,2-diol identical with the natural compound as determined by UV, M+, TLC, and reported IR spectra (Lingens and Goebel, 1967).…”

“…The high-resolution data (Table II) and spectral interpretation of compound A-2 are consistent with 3-(3,-3-diindolyl)propane-l,2-diol. Synthesis of A-2 by a minor modification of reported procedures (Lingens and Goebel, 1967) proved the natural and synthetic materials identical (UV, TLC, M+).…”

“…At 4-5 pg each, A-2 plus B resulted in 40% mortality (2 out of 5 eggs). The toxicity observed for the solution of these alkaloids was probably due to the synergism of A-2 and The 3-indoleglycerol (B, M+ 207) has been isolated from tryptophan requiring mutants of Escherichia coli, Salmonella typhimurium (Lingens et al, 1957), and also from Neurospora crassa (Lingens and Guck, 1963; Garrick et al, 1964); correspondingly blocked mutants of Saccharomyces cereuisiae accumulate 3-(3,3-diindolyl)propane-l,2-diol (A-2, M+ 306) (Lingens and Goebel, 1967). It has been suggested (Preobrazhenkaya et al, 1969) that the 3-indoleglycerol (M+ 207) may exist as the erythrothreo isomeric mixture under biosynthetic conditions.…”

Clay Catalyzed Reactions of Indole and its Methyl Derivatives with α, β-unsaturated Carbonyl Compounds

“…23−27 The reaction of 1,3-dimethylindole(3) with methyl propiolate (Scheme 2) proceeds with an initial attack at the preferred 3-position of the 1,3-dimethylindole. The intra-molecular arrangement followed by the ring expansion gave the cyclic product, methyl 1,5-dimethyl-1H-benzo[b]azepine-3-carboxylate (7). This reaction is a successful example of the ring expansion under the action of activated acetylenes.…”

Synthesis of Novel 4‐((Substituted bis‐indolyl)methyl)‐benzo‐15‐crown‐5 for the Colorimetric Detection of Hg2+ Ions in an Aqueous Medium

“…Much important bis‐indole methane have been widely isolated from various terrestrial and marine natural sources. These natural products have novel structures and exhibit a wide range of biological activities . Cancer chemotherapy with bis‐(3‐indolyl) methane was recently reviewed, and numerous activities have been reported .…”