Zur Aesthesiometrie der Hornhaut nach refraktiver Hornhautchirurgie

Kohlhaas, M.; Draeger, J.; Böhm, AG; Lombardi, Marco; Abbondanza, Marco; Zuppardo, M.; Görne, M.

doi:10.1055/s-2008-1045898

Cited by 15 publications

(3 citation statements)

References 6 publications

(6 reference statements)

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“…3 Surgery-related injury to corneal innervation results in transient or persistent clinical changes to corneal function and may cause post-operative complications such as dry eye syndrome, neurotrophic epitheliopathy, photophobia, hypoesthesia, and persistent epithelial defects. 4–7 Mitomycin C (MMC) used with photorefractive keratectomy (PRK) also has the potential to alter nerve morphology and function but few studies have investigated this possibility. 8 This study aimed to better characterize corneal nerve injury and regeneration after PRK performed with and without MMC in a rabbit model.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Photorefractive Keratectomy and Mitomycin C on Corneal Nerves and Their Regeneration

Medeiros¹,

Marino²,

Lassance³

et al. 2018

J Refract Surg

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Purpose: To determine how PRK and MMC impact corneal nerves and their regeneration over time after surgery. Methods: Twenty-eight New Zealand rabbits had: corneal epithelial scrape with MMC 0.02% (n=3) and without MMC (n=3), −9.0 diopter PRK with MMC (n=6) and without MMC (n=16). Corneas were removed after euthanasia and corneal nerve morphology was evaluated using acetylcholinesterase immunohistochemistry and β-III tubulin staining after 1 day for all the groups, after 1 month for PRK with and without MMC, and 2, 3 and 6 months after PRK without MMC. Image-Pro was used to quantitate the area of nerve loss after the procedures and, consequently, regeneration of the nerves overtime. Opposite eyes were used as controls. Result: Epithelial scrape with MMC treatment did not show a statistically significant difference in nerve loss compared to epithelial scrape without MMC (p=0.4). PRK with MMC was significantly different from PRK without MMC at 1 day after surgery (p=0.0009) but not different at one month after surgery (p=0.9). In the PRK without MMC group, nerves regenerated at two months (p=<0.0001) but did not return to the normal preoperative level of innervation until three months after surgery (p=0.05). However, the morphology of the regenerating nerves was abnormal—with more tortuosity and aberrant innervation compared to the preoperative controls—even at six months after surgery. Conclusion: PRK damages the corneal nerves but they are partially regenerated by three months after surgery in rabbits. Nerve loss after PRK extended peripheral to the excimer laser ablated zone, indicating that there was retrograde degeneration of nerves after PRK. MMC had a small additive toxic effect on the corneal nerves when combined with PRK that was only significant prior to one month after surgery.

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Section: Introductionmentioning

confidence: 99%

The Impact of Photorefractive Keratectomy and Mitomycin C on Corneal Nerves and Their Regeneration

Medeiros¹,

Marino²,

Lassance³

et al. 2018

J Refract Surg

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“…Below, we briefly discuss the three main options available to patients. Other options are available and have been reviewed elsewhere [ 1 , 40 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 ].…”

Section: Clinical Characteristics and Managementmentioning

confidence: 99%

Keratoconus: Tissue Engineering and Biomaterials

Karamichos

Hjortdal

2014

JFB

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Keratoconus (KC) is a bilateral, asymmetric, corneal disorder that is characterized by progressive thinning, steepening, and potential scarring. The prevalence of KC is stated to be 1 in 2000 persons worldwide; however, numbers vary depending on size of the study and regions. KC appears more often in South Asian, Eastern Mediterranean, and North African populations. The cause remains unknown, although a variety of factors have been considered. Genetics, cellular, and mechanical changes have all been reported; however, most of these studies have proven inconclusive. Clearly, the major problem here, like with any other ocular disease, is quality of life and the threat of vision loss. While most KC cases progress until the third or fourth decade, it varies between individuals. Patients may experience periods of several months with significant changes followed by months or years of no change, followed by another period of rapid changes. Despite the major advancements, it is still uncertain how to treat KC at early stages and prevent vision impairment. There are currently limited tissue engineering techniques and/or “smart” biomaterials that can help arrest the progression of KC. This review will focus on current treatments and how biomaterials may hold promise for the future.

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“…(15), Biermann et a!. (5) und Kohlhaas et al (16,17) zeigen, daB die Hornhautsensibilitat noch 3 Jahre nach Epikeratophakie deutlich vermindert ist. Shivitz et a!.…”

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