Zuoguiwan Ameliorates Cognitive Deficits and Neuro-Inflammation in Streptozotocin-Induced Alzheimer’s Disease Rats

Liu, Hong; Zhong, Lili; Dai, Qiaomei; Yang, Jing; Zhang, Yuwei; Zhang, Bo; Jiang, Ying

doi:10.1159/000516396

Cited by 3 publications

(1 citation statement)

References 29 publications

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“… Abstract Intracerebroventricular streptozotocin (ICV-STZ) injection is among the best animal models to simulate sporadic Alzheimer’s disease (AD) (Hoyer, 2002, 2000, 1998; Salkovic-Petrisic and Hoyer, 2007). Brain insulin signaling abnormality (Grünblatt et al, 2007), neurodegeneration (Kamat, 2015), neuroinflammation (Liu et al, 2022), cholinergic damage (Blokland and Jolles, 1993; Roy et al, 2021), mitochondrial dysfunction (C. Correia et al, 2013), genetic abnormality (Chen et al, 2012), respiratory problem (Ebel et al, 2017), oxidative stress (Sharma and Gupta, 2001), gliosis (Rostami et al, 2017), sleep disturbances (Song et al, 2018) associated with cognitive abnormalities seen in ICV-STZ injected rats.…”

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confidence: 99%

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats

Roy

Sharma

Nag

et al. 2022

Preprint

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Intracerebroventricular streptozotocin (ICV-STZ) injection is among the best animal models to simulate sporadic Alzheimer disease (AD) (Hoyer, 2002, 2000, 1998; Salkovic-Petrisic and Hoyer, 2007). Brain insulin signaling abnormality (Grunblatt et al., 2007), neurodegeneration (Kamat, 2015), neuroinflammation (Liu et al., 2022), cholinergic damage (Blokland and Jolles, 1993; Roy et al., 2021), mitochondrial dysfunction (C. Correia et al., 2013), genetic abnormality (Chen et al., 2012), respiratory problem (Ebel et al., 2017), oxidative stress (Sharma and Gupta, 2001), gliosis (Rostami et al., 2017), sleep disturbances (Song et al., 2018) associated with cognitive abnormalities seen in ICV-STZ injected rats. Available experimental evidences has used varying doses of STZ (<1 to 3mg/kg) and studied its effect for different study durations, ranging from 14-21 (short), 30-42 (mild), 90-105 (moderate) and 250-270 (long) days (Chen et al., 2013, 2012; Grunblatt et al., 2007; Knezovic et al., 2015; Kraska et al., 2012; Mehla et al., 2013; Rostami et al., 2017; Salkovic-Petrisic et al., 2006). These studies indicated that 3mg/kg of body weight is the optimum dose for inducing sporadic AD in the rodents. However studies on the pathological process with relating the morphological and functional abnormalities reported were illusive. Therefore in the present study, we have investigated the effect of 3mg/kg ICV-STZ on three cognitive domains viz. spatial, episodic and avoidance and even neuropsychiatric abnormality i.e. anxiety with extensive morphological examination in the layers associated with hippocampus proper. Further, we have observed the onset of diffuse amyloid plaques, in association with enlargement of lateral ventricles and down scaling of spines in granular cells of dentate gyrus. Finally, to dissect the functional changes in spatial and anxiety variables we had examined the probability of fraction of time spent in Morris water maze and changes in ethological patterns of STZ injected rats in elevated plus maze.

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mentioning

confidence: 99%

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats

Roy

Sharma

Nag

et al. 2022

Preprint

View full text Add to dashboard Cite

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Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer’s Disease

Lei,

Xu,

Wang

et al. 2023

DDDT

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Cryopreservation of ram semen: baicalein efficiency on oxidative stress, chromatin integrity, viability and motility post thaw

Avdatek,

Güngör,

Gülhan

et al. 2024

Front. Vet. Sci.

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Baicalein (B) has potential antioxidant properties, but it has not been tested as a ram semen extender. This study aimed to assess the impact of B on various sperm parameters and determine its potential influence on semen quality after the freeze-thawing process. During the breeding season, ejaculates were obtained from four rams with the aid of an artificial vagina. The collected mixed semen samples were divided into four groups: control (C; 0), B0.5 (0.5 mM), B1 (1 mM), and B2 (2 mM). After semen extension, the samples were loaded into 0.25 mL straws and stored for 2 h at 4°C prior to freezing in liquid nitrogen vapor and thawed in a water bath at 37°C. Among the groups, B0.5 demonstrated the highest progressive motility results, while B1 and B2 exhibited reduced motility (p < 0.05). In terms of high mitochondrial membrane potential, plasma membrane and acrosome integrity, and viability, B0.5 showed significantly superior outcomes to the other B groups (p < 0.05), although it was not significantly better than C. B1 displayed the highest plasma membrane integrity levels (p < 0.05). Notably, B2 displayed the lowest total antioxidant status levels among the groups (p < 0.05). The findings of this study suggested that the in vitro spermatological characteristics of ram spermatozoa such as progressive motility and chromatin integrity can be protected from the freeze-thawing process by using the 0.5 mM dose of baicalein as a semen extender. The treatment of sperm freezing might benefit from further in-depth research on the role of B in the improvement of cryoinjury and its underlying processes.

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Zuoguiwan Ameliorates Cognitive Deficits and Neuro-Inflammation in Streptozotocin-Induced Alzheimer’s Disease Rats

Cited by 3 publications

References 29 publications

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats

Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer’s Disease

Cryopreservation of ram semen: baicalein efficiency on oxidative stress, chromatin integrity, viability and motility post thaw

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