Zum Verhalten Der Sekundären Wand Der Uteroplacentargefässe Bei Der Decidualen Reaktion

Brettner, Alfred

doi:10.1159/000142564

Cited by 33 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior to trophoblast invasion, the walls of spiral arteries undergo a variety of reorganization processes including widening of the vessel lumen (Brettner 1964), swelling of smooth muscle cells (Craven et al 1998) and vacuolation of endothelial cells (Boyd and Hamilton 1967). During the invasion period, a subpopulation of EVT, endovascular trophoblasts , invades from the uterine interstitium into maternal spiral arteries and subsequently lines and remodels them.…”

Section: Introductionmentioning

confidence: 99%

The trophoblast plug during early pregnancy: a deeper insight

Weiss

Sundl

Glasner³

et al. 2016

Histochem Cell Biol

View full text Add to dashboard Cite

During the first trimester of pregnancy, foetal endovascular trophoblasts invade into maternal spiral arteries, accumulate and form plugs in the lumen of the vessels. These plugs only allow blood plasma to seep through. Hence, during the first trimester of pregnancy, a first flow of fluids through the placental intervillous space is established, resulting in a physiological oxygen gradient between mother and foetus. The trophoblast plugs block spiral arteries until the beginning of the second trimester (11–14 weeks). In parallel, uterine glands are invaded and opened by endoglandular trophoblasts towards the intervillous space of the placenta, without showing the formation of plugs (Moser et al. in Hum Reprod 25:1127–1136, 2010, Hum Reprod Oxf Engl 30:2747–2757, 2015). This enables histiotrophic nutrition of the embryo prior to onset of maternal blood flow into the placenta. Failure of these endovascular and endoglandular invasion processes may lead to miscarriage or pregnancy disorders such as intrauterine growth restriction (IUGR). After dissolution of the plugs, the onset of maternal blood flow allows maternal blood cells to enter the intervillous space and oxygen concentrations rise up. In this study, we demonstrate for the first time serial cross sections through a trophoblast plug in a first trimester placental bed specimen. Invaded and plugged arteries as well as invaded uterine glands in week 11 of gestation are visualized with specific immunohistochemical double staining techniques. We show that spiral artery plugs appear throughout the placental invasion zone and illustrate erythrocytes stowed due to trophoblast plugs. In addition, we give evidence of the presence of MMP-1 in plugs of invaded spiral arteries. The results reveal a better understanding and a closer insight into the morphological appearance of trophoblast plugs and the consequences for placental and uterine blood flow.

show abstract

Section: Introductionmentioning

confidence: 99%

The trophoblast plug during early pregnancy: a deeper insight

Weiss

Sundl

Glasner³

et al. 2016

Histochem Cell Biol

View full text Add to dashboard Cite

show abstract

“…It is known that as soon as implantation begins decidualisation occurs within the stromal cells and in the ground substance of the endometrium. It is thought that prior to endovascular trophoblast migration, there is true decidualisation of the spiral arteries of the endometrium (Brettner 1964) and other structural changes occur in the myometrial spiral arteries (Brosens 1975). The signal intensity changes and the loss of integrity of the normal zonal uterine anatomy demonstrated by MRI may be due to these local changes in blood flow underlying the implantation site.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging changes in uterine zonal anatomy during a conception cycle

Turnbull¹,

Manton²,

Horsman³

et al. 1995

BJOG

View full text Add to dashboard Cite

“…Theories started with a joint blood system of the mother and fetus and only in the 18th century did the separation of both blood systems become apparent (Hunter, 1980). In the mid 20th century, further evidence was provided suggesting that the uterine spiral arteries undergo morphological alterations even prior to the presence of any extravillous trophoblast cell near such vessels (Boyd & Hamilton 1956, 1967; Brettner 1964; Harris & Ramsey, 1966). These trophoblast‐independent alterations comprised endothelial vacuolation and swelling of smooth muscle cells.…”

Section: Transformation Of the Uterine Spiral Arteriesmentioning

confidence: 99%

“…All these changes lead to a vasodilatation of a certain degree, which is considered to be further increased by the activation of the local decidual artery renin‐angiotensin systems of the mother (Morgan et al. 1998) linked to early endometrial decidualization (Brettner 1964).…”

Section: Transformation Of the Uterine Spiral Arteriesmentioning

confidence: 99%

Oxygen as modulator of trophoblast invasion

et al. 2009

View full text Add to dashboard Cite

At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidual interstitium, extravillous trophoblasts potentially reach and transform spiral arteries into uteroplacental arteries. Spiral arterial erosion starts at about mid-first trimester, whereas flow of maternal blood into the intervillous space is continuously established only at the beginning of the second trimester. One key regulator of the number of extravillous trophoblasts is oxygen. The steep gradient in oxygen concentration within the first trimester placenta is diminished with the onset of maternal blood flow. This gradient is used by the trophoblast to generate a large number of invasive cells to adapt the arterial vasculature in the placental bed to the growing needs of the fetus. Changes in oxygen concentrations or other factors leading to alterations in the rates of proliferation and/or apoptosis of extravillous trophoblast clearly impact on the remodelling of the vessels. The respective consequences of a failure in trophoblast invasion are growth restrictions of the baby and perhaps other pregnancy complications.

show abstract

Zum Verhalten Der Sekundären Wand Der Uteroplacentargefässe Bei Der Decidualen Reaktion

Cited by 33 publications

References 0 publications

The trophoblast plug during early pregnancy: a deeper insight

The trophoblast plug during early pregnancy: a deeper insight

Magnetic resonance imaging changes in uterine zonal anatomy during a conception cycle

Oxygen as modulator of trophoblast invasion

Contact Info

Product

Resources

About