Zum Nachweis von Pentazocin (Fortral) im menschlichen Harn: Gaschromatographisch/massenspektrometrische Untersuchungen

Abstract

After oral application of pentacozine (Fortral) besides the unchanged drug some further excretion products were detected by glc/ms in human urine. For their identification e.i.-and c.i.-mass-spectrometry as well as the just recently available FAB-technique were employed. All analyses were performed on a VG-Micromass 7035; the samples were introduced in the ion source via a fused silica, bonded phase capillary column (30 metres; DB-1 J + W, Inc.). The analytical profiles of the pure substance and some metabolites are reported as well as the behaviour of the pure substance on acidic hydrolyzation.

Forensic science

“…Toxicological and pathological findings in fatalities involving pentazocine and tripenlenamine have been described including procedures such as TLC, GC, UV, and spectrofluorimetry (220). Pentazocine has also been detected by GC/MS (221,222), and HPLC (223).…”

FAB (Fast Atom Bombardment)-Massenspektrometrie

“…Als Ebenfalls mit der FAB-MS wurde das Molekulargewicht des bei der salzsauren Hydrolyse des Pentazocins (Fortral) quantitativ entstehenden Pentazocin-Hydrats bestimmt [10,11]. …”

Untersuchungen �ber die Spaltung von synthetischem Pentazocin-Glucuronid mit Salzs�ure

“…). 1) bildet(Kigasawa et al 1976;Reid et al 1981;Gielsdorf et al 1982), wodurch die Pentazocin-Ausbeute verringert wird. 1)(Berkowitz et al 1969).Die Glucuronidsplatung stellt deshalb einen wichtigen Schritt beim Nachweis eines fraglichen Pentazocin-Konsums dar; es ist abet bekannt, dal3 1 durch s~urekatalysierte Hydratisierung der Allylseitenkette das Artefakt III (Abb.…”