ZSCAN25 and CYP2E1 polymorphisms is risk factors for ischemic stroke in a Chinese Han population: a case control study

Abstract

Background We aimed to explore the relationship between ZSCAN25 and CYP2E1 polymorphisms and Ischemic stroke (IS) susceptibility among a Chinese Han population. Methods We enrolled 477 patients with IS and 480 age- and sex- matched health controls. Genotyping of the ZSCAN25 rs10242455, CYP2E1 rs2070672 and rs2515641 were performed by Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression analysis. Results Rs10242455 (OR = 0.56, 95% CI: 0.34–0.93, p = 0.024) was associated with a reduced IS susceptibility, while rs2070672 (OR = 1.40, 95% CI: 1.12–1.75, p = 0.003) and rs2515641 (OR = 1.29, 95% CI: 1.01–1.64, p = 0.041) with an increased IS occurrence. Rs2070672 was observed to correlate with IS risk (OR = 4.06, p = 0.038) at age > 64 years, and rs10242455 (OR = 0.45, p = 0.021) and rs2070672 (OR = 3.28, p = 0.024) affected IS risk in males. In addition, rs10242455 (OR = 1.72, p = 0.014) was significantly associated with hypertension in IS patients. Conclusion Our study firstly found that rs10242455 in ZSCAN25, rs2070672 and rs2515641 in CYP2E1 were associated with the occurrence of IS in a Chinese Han population.

Association between polymorphisms in miRNAs and ischemic stroke: A meta-analysis

“…Figure 1 shows the progress of study selection. Among these studies, 17 studies focused on miR-146a G>C (rs2910164), [31,32,[34][35][36][37][38][39][40][41][43][44][45][46][47]51,52] 9 studies focused on miR-149 T>C (rs2292832), [33][34][35][42][43][44]46,49,50] 10 studies focused on miR-196a2 T>C (rs11614913), [34,[36][37][38][42][43][44]46,47,50] and 11 studies focused on miR-499 A>G (rs3746444). [34,36,38,41,43,44,[46][47][48][49]52] From the included studies, 17 were from China, 2 from Egypt, 2 from South Korea and 1 from Iran.…”