ZrO₂-supported Cu(ii)–β-cyclodextrin complex: construction of 2,4,5-trisubstituted-1,2,3-triazoles via azide–chalcone oxidative cycloaddition and post-triazole alkylation

Abstract

The ZrO2–Cu2–β-CD complex is an excellent catalyst for the synthesis of N-2-alkylated-1,2,3-triazoles.

Synthetic Application of Cyclodextrins in Combination with Metal Ions, Complexes, and Metal Particles

“…It was used in triazole synthesis by reacting chalcones and NaN 3 followed by N-alkylation with esters in one pot. [171] Recently, they tested their catalyst in 2H-tetrazole synthesis starting from benzonitriles following the same protocol. [172] Transformations required long treatments and an unusually high catalyst loading of 40 mol % (Scheme 50).…”

Crystal structure analysis of [5-(4-methoxyphenyl)-2-methyl-2H-1,2,3-triazol-4-yl](thiophen-2-yl)methanone

“…A Cambridge Structural Database (Version 5.39, update May 2018; Groom et al, 2016) search for the (2-methyl-2H-1,2,3triazol-4-yl)(thiophen-2-yl)methanone subunit resulted in one hit (SONFIM; Girish et al, 2014). Like compound 1, the molecular conformation of SONFIM is also stabilized by intramolecular C-HÁ Á ÁO and C-HÁ Á ÁN hydrogen bonds.…”

“…The title compound was synthesized according to the procedure described elsewhere (Girish et al, 2014). Single crystals of the pure compound were grown by slow evaporation of a toluene solution at room temperature (297-301 K).…”

Cu (II)-β-CD as Water-Loving Catalyst for One-Pot Synthesis of Triazoles and Biofuels Intermediate at Room Temperature without Any Other Additive

“…Major drawbacks of these reactions are use of aryboronic acid as substrate. Girish et al., reported ZrO 2 ‐supported Cu(II)‐β‐CD complex for synthesis of 1,2,3‐triazoles from chalcones . 1,2,3‐Triazoles have been found vast application in biology, chemistry and material science, many of the 1,2,3‐triazoles have found medicinal applications, such as HIV protease inhibitors, anticancer drugs, antifungal, antituberculosis drugs, antibacterial drugs and they are also used as corrosion inhibitors, photostabilizers, lubricants and dyes .…”