Zr(HSO4)4 and Mg(HSO4)2 as mild and efficient catalysts for the one-pot multicomponent synthesis of β-acetamido carbonyl compounds

Synthesis of Amido Carbonyl Compounds through the Dakin–West Reaction using Lewis Acid Catalysts

“…34 A wide variety of aromatic aldehydes and acetophenones, containing both electron withdrawing and donating substituents were treated and the corresponding β-acetamido ketones were obtained in good to excellent yields. α,β-Unsaturated aldehydes such as cinnamaldehyde also reacted under the same experimental conditions and provided the desired product.…”

“…In another procedure, synthesis of β-acetamido carbonyl compounds by the one-pot multicomponent coupling of an aromatic aldehyde, an enolisable ketone or ketoester, acetonitrile, and Scheme 19 Scheme 20 acetyl chloride using Zr(HSO 4 ) 4 and Mg(HSO 4 ) 2 as mild, inexpensive, and highly efficient catalysts was studied. 34 A wide variety of aromatic aldehydes and acetophenones, containing both electron withdrawing and donating substituents were treated and the corresponding β-acetamido ketones were obtained in good to excellent yields. α,β-Unsaturated aldehydes such as cinnamaldehyde also reacted under the same experimental conditions and provided the desired product.…”

Novel bi-SO3H-functionalized ionic liquids based on piperazinium: Highly efficient and recyclable catalysts for the synthesis of β-acetamido ketones

“…Recently, it is reported that ␤-acetamido ketones can act as aglucosidase inhibitors [19]. ␤-Acetamido ketones have been synthesized through MCRs using Zr(HSO 4 ) 4 [20], Mg(HSO 4 ) 2 [20], Cu(OTf) 2 [21], H 3 …”

Solvent‐Free Synthesis of 1,8‐Dioxo‐octahydroxanthenes and 14‐Aryl‐14H‐dibenzo[a,j]xanthenes using Saccharin SulfonicAcid as an Efficient and Green Catalyst

“…In recent years, the use of sulfonic acid-containing catalysts and reagents has gained considerable attention in organic synthesis, due to their unique properties such as enhanced reactivity as well as selectivity, efficiency, straightforward workup, easy availability of their starting materials, eco-friendly reaction conditions and ability to promote a wide range of reactions [26][27][28][29][30][31][32][33][34][35][36][37][38][39] . They are also non-toxic, non-corrosive and inexpensive.…”