Zotepine‐induced convulsion at a low dose in a case of paranoid schizophrenia

Ali, Mustafa; Das, Soumitra

doi:10.1111/pcn.12640

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Notably, the minimum convulsion risk dose of ZTP (350 mg/day) is within approved the therapeutic daily dose (150~450 mg/day) [17,62,63]. Furthermore, the average time of onset for convulsions of ZTP (7 weeks) [17,62,63] was faster than that of clozapine (12 weeks) [60,61]. Therefore, these previous clinical reports suggested that ZTP seems to be an atypical antipsychotic with a higher risk of convulsion compared with clozapine.…”

Section: A Candidate Mechanism Of the Clinical Action Of Ztp Associated With Astrocytesmentioning

confidence: 92%

“…A study on a large sample reported that the incidence of ZTP-induced convulsion was approximately 6~17% (7/115 and 22/129) [17,18]. The risk dosage of ZTP for convulsions was over 150~350 mg/kg/day and the average duration was 21~49 days [17,62,63]. The rapid titration of doses is also a risk factor of ZTP-and clozapine-induced convulsions [60,61].…”

Section: A Candidate Mechanism Of the Clinical Action Of Ztp Associated With Astrocytesmentioning

confidence: 99%

“…The rapid titration of doses is also a risk factor of ZTP-and clozapine-induced convulsions [60,61]. Notably, the minimum convulsion risk dose of ZTP (350 mg/day) is within approved the therapeutic daily dose (150~450 mg/day) [17,62,63]. Furthermore, the average time of onset for convulsions of ZTP (7 weeks) [17,62,63] was faster than that of clozapine (12 weeks) [60,61].…”

Section: A Candidate Mechanism Of the Clinical Action Of Ztp Associated With Astrocytesmentioning

confidence: 99%

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Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion

Fukuyama

Okada

2021

Pharmaceuticals

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Accumulating neuropsychopharmacological evidence has suggested that functional abnormalities of astroglial transmission and protein kinase B (Akt) contribute to the pathophysiology and/or pathomechanisms of several neuropsychiatric disorders, such as epilepsy, schizophrenia, affective disorders and antipsychotic-induced convulsions. Therefore, to explore the pathophysiology of mood-stabilising antipsychotics and the proconvulsive actions of atypical antipsychotics, the present study determined the effects of a mood-stabilising, atypical, antipsychotic agent, zotepine (ZTP), on astroglial L-glutamate release and the expression of connexin43 (Cx43) protein in cortical, primary, cultured astrocytes using ultra-high-pressure liquid chromatography and capillary immunoblotting systems. Both acute and subchronic administrations of therapeutically relevant concentrations of ZTP did not affect astroglial L-glutamate release or Cx43 expression in plasma membranes; however, chronic administration of a therapeutically relevant concentration of ZTP increased astroglial L-glutamate release and Cx43 expression in the plasma membrane. Subchronic administrations of a supratherapeutic concentration of ZTP enhanced astroglial L-glutamate release and Cx43 expression in the plasma membrane, whereas acute administration of a supratherapeutic concentration of ZTP enhanced astroglial L-glutamate release without affecting Cx43 expression. These stimulatory effects of ZTP on astroglial L-glutamate release through activated hemichannels and Cx43 trafficking to the astroglial plasma membrane were suppressed by the Akt inhibitor. These results suggest that ZTP enhances astroglial L-glutamate release in a concentration-dependent and time-dependent manner due to the enhanced function of astroglial hemichannels, probably via activation of Akt signalling. Therefore, the enhanced astroglial L-glutamatergic transmission induced by ZTP is, at least partially, involved in the mood-stabilising antipsychotic and proconvulsive actions of ZTP.

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Section: A Candidate Mechanism Of the Clinical Action Of Ztp Associated With Astrocytesmentioning

confidence: 92%

Section: A Candidate Mechanism Of the Clinical Action Of Ztp Associated With Astrocytesmentioning

confidence: 99%

Section: A Candidate Mechanism Of the Clinical Action Of Ztp Associated With Astrocytesmentioning

confidence: 99%

See 1 more Smart Citation

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion

Fukuyama

Okada

2021

Pharmaceuticals

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Zotepine

2018

Reactions Weekly

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Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia

Yoshida

Takeuchi

2021

Behavioural Brain Research

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Zotepine‐induced convulsion at a low dose in a case of paranoid schizophrenia

Cited by 3 publications

References 5 publications

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion

Zotepine

Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia

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