Zosteriform Keratosis Follicularis Treated Topically With Tretinoin

Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature

“…Although the use of tretinoin (also known as all-trans-retinoic acid, retinoic acid or vitamin A acid) was the most frequently reported topical treatment for DD, the evidence for its efficacy was contradictory and of limited quality (Grade C). 8 , 12 , 19 , 57 - 64 In Goh’s retrospective study of eight patients treated with topical retinoic acid, only two experienced mild benefit from this treatment. 12 In one controlled trial of one patient with DD, areas treated with topical all-trans-retinoic acid were moderately improved, meanwhile placebo-treated areas were unchanged.…”

“… 64 In 12 alternate cases, however, therapy with tretinoin resulted in partial to complete remission of DD. 19 , 57 - 64 Among patients, side effects of mild itching and tenderness, inflammation and desquamation were reported. 57 , 58 Therapy with all-trans-retinoic acid was ultimately discontinued in two patients in Goh’s study, and the single patient in the control trial due to side effects of severe irritation, erythema and burning.…”

“… 19 , 57 - 64 Among patients, side effects of mild itching and tenderness, inflammation and desquamation were reported. 57 , 58 Therapy with all-trans-retinoic acid was ultimately discontinued in two patients in Goh’s study, and the single patient in the control trial due to side effects of severe irritation, erythema and burning. 12 , 64 In Burge et al’s retrospective non-comparative cohort study of 163 patients with DD, it was reported that all patients who had been prescribed topical retinoic acid eventually discontinued treatment as it had a tendency to irritate skin.…”

The Surgical Treatment of Hypertrophic Darier's Disease

“…Unusual reported variants of Darier's disease include a bullous type, 10–13 a zosteriform or linear type, 14,15 a unilateral type, 16 and, perhaps the most severe, a widespread hypertrophic type 17–20 . In this type, the lesions become markedly thickened and hyperkeratotic, resulting in the development of wartlike masses and plaques.…”