Zosteriform Keratosis Follicularis Treated Topically With Tretinoin

Hesbacher, Edwin N.

doi:10.1001/archderm.1970.04000080081016

Cited by 20 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the use of tretinoin (also known as all-trans-retinoic acid, retinoic acid or vitamin A acid) was the most frequently reported topical treatment for DD, the evidence for its efficacy was contradictory and of limited quality (Grade C). 8 , 12 , 19 , 57 - 64 In Goh’s retrospective study of eight patients treated with topical retinoic acid, only two experienced mild benefit from this treatment. 12 In one controlled trial of one patient with DD, areas treated with topical all-trans-retinoic acid were moderately improved, meanwhile placebo-treated areas were unchanged.…”

Section: Resultsmentioning

confidence: 99%

“… 64 In 12 alternate cases, however, therapy with tretinoin resulted in partial to complete remission of DD. 19 , 57 - 64 Among patients, side effects of mild itching and tenderness, inflammation and desquamation were reported. 57 , 58 Therapy with all-trans-retinoic acid was ultimately discontinued in two patients in Goh’s study, and the single patient in the control trial due to side effects of severe irritation, erythema and burning.…”

Section: Resultsmentioning

confidence: 99%

“… 19 , 57 - 64 Among patients, side effects of mild itching and tenderness, inflammation and desquamation were reported. 57 , 58 Therapy with all-trans-retinoic acid was ultimately discontinued in two patients in Goh’s study, and the single patient in the control trial due to side effects of severe irritation, erythema and burning. 12 , 64 In Burge et al’s retrospective non-comparative cohort study of 163 patients with DD, it was reported that all patients who had been prescribed topical retinoic acid eventually discontinued treatment as it had a tendency to irritate skin.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature

et al. 2021

View full text Add to dashboard Cite

Darier’s disease (also known as keratosis follicularis or dyskeratosis follicularis) is an autosomal dominant inherited disorder which manifests as hyperkeratotic greasy papules in the first or second decade of life. Aside from symptom management and behavioral modifications to avoid triggers, there are currently no validated treatments for Darier’s disease (DD). However, a variety of treatments have been proposed in the literature including retinoids, steroids, vitamin D analogs, photodynamic therapy, and surgical excision. The purpose of this review article is to identify therapeutic options for treating DD and to outline the evidence underlying these interventions. A search was conducted in Medline for English language articles from inception to July 4, 2020. Our search identified a total of 474 nonduplicate studies, which were screened by title and abstract. Of these, 155 full text articles were screened against inclusion/exclusion criteria, and 113 studies were included in our review. We identified Grade B evidence for the following treatments of DD: oral acitretin, oral isotretinoin, systemic Vitamin A, topical tretinoin, topical isotretinoin, topical adapalene gel, topical 5-flououracil, topical calciptriol and tacalcitol (with sunscreen), grenz ray radiation, and x-ray radiation. All other evidence for treatments of DD consisted of case reports or case series, which is considered grade C evidence. Considering the quality and quantity of evidence, clinicians may consider initiating a trial of select topical or oral retinoids first in patients with localized or generalized DD, respectively.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Unusual reported variants of Darier's disease include a bullous type, 10–13 a zosteriform or linear type, 14,15 a unilateral type, 16 and, perhaps the most severe, a widespread hypertrophic type 17–20 . In this type, the lesions become markedly thickened and hyperkeratotic, resulting in the development of wartlike masses and plaques.…”

mentioning

confidence: 99%