Zosteriform cutaneous T-cell lymphoma

Ricci, Rita M.; Latham, Phillip Lane; Soong, Vera Y.; Mullins, Diane

doi:10.1016/0190-9622(95)90211-2

Cited by 15 publications

(12 citation statements)

References 2 publications

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“…The histotype of primary malignant tumor was various, with a relevant percentage of hematological malignancy and breast and skin carcinomas. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][44][45][46][47][48][49][50] Melanoma accounted for 19.6%, justifying the larger series of zosteriform metastases reported to date, with 11 of 56 cases described so far. [31][32][33][34][35][36][37][38] However, the prevalence of zosteriform metastases is lower than that of cutaneous melanoma localizations.…”

Section: Discussionmentioning

confidence: 99%

Zosteriform Cutaneous Metastases

Savoia

Fava

Deboli

et al. 2009

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 99%

Zosteriform Cutaneous Metastases

Savoia

Fava

Deboli

et al. 2009

Dermatologic Surgery

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“…In our case, multiple scaly erythemas were distributed in a zosteriform pattern on the right abdomen. To our knowledge, there have only been two similar cases of lymphomas presenting in a zosteriform pattern (10, 11). The term ‘zosteriform’ refers to a skin lesion following a dermatological distribution, without previous herpes zoster reactivation (12).…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous T‐Cell‐Rich B‐Cell Lymphoma in a Zosteriform Distribution Associated with Epstein‐Barr Virus Infection

Watabe

Kawakami

Soma

et al. 2002

The Journal of Dermatology

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T-cell-rich B-cell lymphoma (TRBL) is a lately recognized B-cell lymphoma variant characterized by a minor population of neoplastic B cells existing in a background of predominant polyclonal T cells. We report an 86-year-old man with primary cutaneous TRBL associated with Epstein-Barr (EB) virus infection. Clinically, palpable scaly erythemas were distributed in a zosteriform pattern on the right abdomen. Histologically, massive cellular infiltrates were located in the upper- and mid-dermis. Higher magnification showed that the cellular infiltration was composed mainly of abnormal mononuclear, large lymphoid cells with clear cytoplasm and scattered mitoses and small lymphocytes, which represented in excess of 75% of all the infiltrating cells. Immunohistochemical staining revealed that the large cells were positive for the B cell marker, CD20, but negative for the T cell marker, CD3. On the other hand, the small cells were positive for CD3, but negative for CD20. Polymerase chain reaction (PCR) revealed EB virus DNA in the skin lesion. Primary cutaneous TRBL has only been reported in 15 cases worldwide. To our knowledge, this is the first case of primary cutaneous TRBL in a zosteriform distribution reported in the literature and the second case of primary cutaneous TRBL associated with the EB virus infection. We postulate that the EB virus may be a contributory pathogenetic event leading to monoclonal B-cell proliferation.

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“…There is one reported case of leukemia cutis arising in a herpes zoster scar in a patient previously diagnosed with B-cell chronic lymphocytic leukemia [ 10 ]. In another reported case, a patient had herpes zoster-like lesions for 2 years and was eventually diagnosed with zosteriform T-cell lymphoma [ 11 ]. Additionally, there was one reported case of acute infiltration of B-cell lymphoma in disseminated herpes zoster lesions [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Large B-Cell Lymphoma at the Site of a Herpes Zoster Scar

et al. 2012

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Herpes zoster, also known as shingles, occurs upon reactivation of a primary infection with varicella zoster virus (VZV). Risk factors for reactivation include stress, older age, and immunosuppression, all of which are associated with a decrease in host immunity. Common complications of herpes zoster include scarring and post-herpetic neuralgia (PHN). Cutaneous lesions such as granuloma annulare, lymphomas, and sarcoid granulomas have also been reported to potentially arise at the site of herpes zoster. Here, we report a case that to our knowledge is the first presentation of diffuse large B-cell lymphoma with its only cutaneous manifestation arising in a herpes zoster scar. Punch biopsy was performed on a nodule appearing in a dermatomal distribution within the herpes zoster scar. Histopathology revealed an atypical lymphoid infiltrate in the dermis that was determined to be CD20 positive B-cells. Immunostains for CD20, CD79a, and PAX-5 showed strong positive staining of the atypical cells, confirming B-cell origin and resulting in the diagnosis of lymphoma, large B-cell type. This case highlights the importance of raising clinical suspicion for a malignant process in patients who present with a changing or unresolving skin manifestation after infection with varicella zoster virus.

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Zosteriform cutaneous T-cell lymphoma

Cited by 15 publications

References 2 publications

Zosteriform Cutaneous Metastases

Zosteriform Cutaneous Metastases

Primary Cutaneous T‐Cell‐Rich B‐Cell Lymphoma in a Zosteriform Distribution Associated with Epstein‐Barr Virus Infection

Diffuse Large B-Cell Lymphoma at the Site of a Herpes Zoster Scar

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