Zoonoses in the Bedroom

Chomel, Bruno B; Sun, Ben

doi:10.3201/eid1702.101070

Cited by 156 publications

(112 citation statements)

References 36 publications

(44 reference statements)

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“…In Europe and USA, up to 45% of pet dogs sleep in their owner's beds, 21 enabling several zoonotic agents, such as pasteurellas, MRSAs, and giardias, to infect the owner. Infection may also occur when owners kiss or are licked by their pets.…”

Section: Discussionmentioning

confidence: 99%

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Pet dogs—A transmission route for human noroviruses?

Summa¹,

Bonsdorff²,

Maunula³

2012

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 99%

“…Infection may also occur when owners kiss or are licked by their pets. 21 These routes may also be possible for NoV transmission. Humans with NoV infection secrete high amounts of the virus in faeces and vomit during the acute phase of infection.…”

Section: Discussionmentioning

confidence: 99%

Pet dogs—A transmission route for human noroviruses?

Summa¹,

Bonsdorff²,

Maunula³

2012

Journal of Clinical Virology

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“…In the United States (US), 75% of cats sleep with humans. 1 Presently, there are 95.6 million household cats in the US.…”

Section: Introductionmentioning

confidence: 99%

Zoonotic Bacteria Associated with Cats

Hariharan¹,

Hariharan²

2017

Vet Med Open J

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CitationHariharan H, Hariharan SH. Zoonotic bacteria associated with cats. Vet Med Open J. 2017; 2(3): 68-75. doi: 10.17140/VMOJ-2-118 ABSTRACT Background: There are several bacterial pathogens, including Bartonella, and Pasteurella that have been known to cause human infections from contact with cats. Recently, certain bacteria have emerged as causes of infection in cats, resulting in transmission to humans. Objectives: This review presents updated information on the zoonotic bacterial pathogens associated with cats, with special emphasis on recent reports. Results: Presently, an increase in the incidence of cat-associated Yersinia pestis human infections in the western USA has become a concern. In addition, infections due to Mycobacterium bovis, and Brucella abortus, are being recognized. Also, a number of human infections due to Campylobacter, Helicobacter, and Salmonella from cats have been documented worldwide. In addition, spread of bacteria resistant to antimicrobial drugs from cats is becoming a possibility. Conclusion: Updated information shows that more zoonotic bacteria than previously recognized are associated with cats worldwide. Immunocompromised persons and young children are particularly at a risk of developing infection from household cats which are allowed to roam around outdoors. It is important to incorporate environmental and animal contact considerations into patient care. With proper handling and precautions, cats can help establish valuable humananimal bonds.

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“…We experimented with Pasteurella multocida , which is both an important pathogen of animals, in particular cattle910, and a zoonotic bacteria with a wide host range and commonly present in infected animal wound bites in humans111213. The antimicrobial was the fluoroquinolone enrofloxacin, which is thought to exhibit the concentration-dependent activity against this pathogen14.…”

mentioning

confidence: 99%

Limitations of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibilities within a single bacterial species

Wen

Gehring

Stallbaumer

et al. 2016

Sci Rep

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The minimum inhibitory concentration (MIC) of an antimicrobial drug for a bacterial pathogen is used as a measure of the bacterial susceptibility to the drug. However, relationships between the antimicrobial concentration, bacterial susceptibility, and the pharmacodynamic (PD) inhibitory effect on the bacterial population are more complex. The relationships can be captured by multi-parameter models such as the Emax model. In this study, time-kill experiments were conducted with a zoonotic pathogen Pasteurella multocida and the fluoroquinolone enrofloxacin. Pasteurella multocida isolates with enrofloxacin MIC of 0.01 μg/mL, 1.5 μg/mL, and 2.0 μg/mL were used. An additive inhibitory Emax model was fitted to the data on bacterial population growth inhibition at different enrofloxacin concentrations. The values of PD parameters such as maximal growth inhibition, concentration achieving a half of the maximal inhibition, and Hill coefficient that captures steepness of the relationships between the concentration and effect, varied between the isolate with low MIC and less susceptible isolates. While enrofloxacin PD against the isolate with low MIC exhibited the expected concentration-dependent characteristics, the PD against the less susceptible isolates demonstrated time-dependent characteristics. The results demonstrate that bacterial antimicrobial susceptibility may need to be described by a combination of parameters rather than a single parameter of the MIC.

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Zoonoses in the Bedroom

Cited by 156 publications

References 36 publications

Pet dogs—A transmission route for human noroviruses?

Pet dogs—A transmission route for human noroviruses?

Zoonotic Bacteria Associated with Cats

Limitations of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibilities within a single bacterial species

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