Zooming in on adipocytes: High and deep

Doan, Minh

doi:10.1002/cyto.a.23269

Cited by 1 publication

(1 citation statement)

References 14 publications

(24 reference statements)

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“…These techniques will further reveal the complex nature of the mechanisms by which extrinsic factors regulate signal transduction and cell-fate decisions of hematopoietic stem cells. In addition to studies in genetic mouse models, transcriptomic and single cell analysis after fluorescence Communication to the Editor activated cell sorting of live cells represent fundamental tools that will help us understand the roles of adipocytes within the bone marrow microenvironment (81)(82)(83)(84). In spite of powerful experimental mouse models providing a proof of concept for adipocytes biology in the bone marrow, we are still lacking direct demonstration of adipocytes roles in the human bone marrow.…”

Section: Perspectives/future Directionsmentioning

confidence: 99%

Adipocytes role in the bone marrow niche

et al. 2017

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Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) by using state-of-the-art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage-tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes’ roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders.

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Section: Perspectives/future Directionsmentioning

confidence: 99%