Zoom endoscopic monitoring of small bowel allograft rejection

PURPOSE:To evaluate the current model of small bowel resection and intestinal transplantation in pigs. METHODS:Forty two Large White pigs were distributed in five groups: G1(n=6), G2(n=6) and G3(n=6) were submitted to 80%,100% and 100% plus right colon resection respectively and G4(n=7) and G5(n=5) to 100% SBR plus IT without and with immunosuppression based on Tacrolimus and Mycophenolic acid. Evaluation included weight control, clinical status, biochemical analysis and endoscopies for graft biopsies. Follow-up in G1 and 2 was 84 days, while in G3, four and five was ± three weeks.RESULTS: G1 increased weight suggesting adaptation while G2 and 3 loused weight and inadequate adaptation. G4 and 5 died of acute cellular rejection (ACR) and sepses respectively. Overall survival in G1, 2, 3, 4 and 5 at 30 days was 100, 100, 0 and 20 %, respectively.Medium survival in G4 and 5 was 14 and 16 days. CONCLUSIONS:The resection of 80% of small intestine in pigs is not suitable for short bowel syndrome induction. Intestinal transplantation with the proposed immunosuppression protocol was effective in prevent the occurrence of severe acute rejection, but inappropriate to increase recipients survival.

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“…High resolution endoscopy with magnification of images enabled the view of "almost microscopic" details, becoming the method of election 35 .…”

Section: Total Cholesterolmentioning

confidence: 99%

Outcome of pigs with short gut syndrome submitted to orthotopic intestinal transplantation

et al. 2015

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“…Diagnostic endoscopy alone can help to rule out gross changes in the bowel mucosa. In patients who can accommodate large scopes, zoom endoscopy of the intestinal mucosa allows for an in-depth evaluation of the intestinal villi and defines alterations in their height, shape of the villous tip, erythema of the mucosa, and friability [18].…”

Section: Diagnosismentioning

confidence: 99%

Clinical Allograft Rejection Syndromes in Intestinal Transplantation

Tzakis

Selvaggi

Tekin

et al. 2014

Textbook of Organ Transplantation

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“…Magnification or zoom endoscopes have movable lenses that allow the endoscopist to change the magnification of the endoscopic image [14]. Magnification endoscopes have been used to diagnose rejection after small bowel transplant with reported sensitivity and specificity of 45% and 98%, respectively, in adults and 61% and 84% in children [15,16]. Both highresolution and magnification endoscopy have been used in conjunction with chromoendoscopy for cancer surveillance in Barrett's esophagus in adults [14] and could potentially be used for the same indication in children.…”

Section: Advances In Endoscopic Imagingmentioning

confidence: 99%

Advances and new technologies in adult endoscopy: Can they be adapted to pediatrics?

Croffie

2007

Curr Gastroenterol Rep

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Gastrointestinal endoscopy has revolutionized the management of many gastrointestinal and pancreatobiliary diseases and is now an integral part of the evaluation and treatment of gastrointestinal diseases in children and adolescents. Over the past several years, many new technological and therapeutic advances have been made in the field. These new technologies and therapies are often initially applied to adult patients and gradually adapted to children. This review focuses on recent advances and new technologies in adult endoscopy and discusses their adaptability to pediatric patients and the limitations to their adaptation.

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Zoom endoscopic monitoring of small bowel allograft rejection

Abstract: With the use of magnification, endoscopy is a useful tool for monitoring acute rejection in the small bowel allograft.

Cited by 42 publications

References 32 publications

Outcome of pigs with short gut syndrome submitted to orthotopic intestinal transplantation

Outcome of pigs with short gut syndrome submitted to orthotopic intestinal transplantation

Clinical Allograft Rejection Syndromes in Intestinal Transplantation

Advances and new technologies in adult endoscopy: Can they be adapted to pediatrics?

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