ZOO-FISH analysis: cat and human karyotypes closely resemble the putative ancestral mammalian karyotype

Rettenberger, G.; Klett, Christine; Zechner, Ulrich; Bruch, Jochen; Just, Walter; Vogel, Walther; Hameister, Horst

doi:10.1007/bf00713962

Cited by 125 publications

(110 citation statements)

References 21 publications

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“…It somehow parallels the similarity of the karyotypes, which has been found to be close to the ancestral mammalian chromosome arrangement in both cases. 49 ( Figure 5d). Taken together, this points to high intron identity around alternatively included exons being a more general phenomenon.…”

Section: Resultsmentioning

confidence: 99%

In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons

et al. 2003

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Section: Resultsmentioning

confidence: 99%

In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons

et al. 2003

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“…Todd (1970) suggested that the ancestral karyotype consisted of 14 chromosomes, whereas Matthey (1973) considered a chromosome number of 2n = 48 ‫ע‬ 8 as the ancestral eutherian condition. Still others favored an intermediate chromosome number like that of the cat (Rettenberger et al 1995b). If we analyze the additional information available through various chromosome painting studies hitherto carried out, the different hypotheses mentioned above can be tested, assuming that maximum parsimony should disclose the likely ancestral chromosomes/chromosomal complement.…”

Section: Discussionmentioning

confidence: 99%

“…Comparison of segment numbers detected in the different genomes by human CSLs range from 31 in cat and harbor seal (Rettenberger et al 1995b; to 53 in cattle (Hayes 1995). Variations in segment numbers detected for a particular species by different investigators (e.g., cattle ;Hayes 1995;Solinas-Toldo et al 1995;Chowdhary et al 1996) exclusively concern small segments and most likely reflect variation in complexity and origin of DNA probes applied by different laboratories (e.g., flow sorted or microdissected; see Yang et al 1997;Chaudhary et al 1998).…”

Section: Overall Conservation Of Karyotypic Organizationmentioning

confidence: 99%

“…However, there are no facts against proposing the reverse possibility, wherein the two syntenic groups were on separate chromosomes in the mammalian ancestral complement that later fused in human and carnivores. Nevertheless, with the carnivore and human karyotypes considered as more closely related to the putative ancestral mammalian complement (Rettenberger et al 1995b;, the possibility of the former process appears more likely. A different scenario with respect to the synteny conservation is again apparent in the mouse in which a high degree of rearrangement with respect to HSA6 material is evident.…”

Section: Hsa6mentioning

confidence: 99%

“…The compiled data suggest that the HSA16-HSA19 synteny combination is also an ancient condition (Rettenberger et al 1995b;. With the help of the available gene mapping data, it is possible to trace the regions corresponding to HSA19q and HSA16q in pig, cattle, and horse (see arrows; Fig.…”

Section: Hsa16 and Hsa19mentioning

confidence: 99%

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Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

Chowdhary¹,

Raudsepp²,

Frönicke³

et al. 1998

Genome Res.

211

143

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Although gene maps for a variety of evolutionarily diverged mammalian species have expanded rapidly during the past few years, until recently it has been difficult to precisely define chromosomal segments that are homologous between species. A solution to this problem has come from the development of Zoo-FISH, also known as cross-species chromosome painting. The use of Zoo-FISH to identify regions of chromosomal homology has allowed the transfer of information from map-rich species such as human and mouse to a wide variety of other species. From a Zoo-FISH analysis spanning four mammalian orders (Primates, Artiodactyla, Carnivora, and Perissodactyla), and involving eight species (human, pig, cattle, Indian muntjac, cat, American mink, harbor seal, and horse), three distinct classes of synteny conservation have been designated: (1) conservation of whole chromosome synteny, (2) conservation of large chromosomal blocks, and (3) conservation of neighboring segment combinations. This analysis has also made it possible to identify a set of chromosome segments (based on human chromosome equivalents) that probably made up the karyotype of the common ancestor of the four orders. This approach provides a basis for developing a picture of the ancestral mammalian karyotype, but a full understanding will depend on studies encompassing more diverse combinations of mammalian orders.

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In situ hybridization (FISH) maps chromosomal homologies between Alouatta belzebul (Platyrrhini, Cebidae) and other primates and reveals extensive interchromosomal rearrangements between howler monkey genomes

Consigliere

Stanyon

Koehler³

et al. 1999

Am. J. Primatol.

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We hybridized whole human chromosome specific probes to metaphases of the black‐and‐red howler monkey Alouatta belzebul in order to establish chromosomal homology between humans and black‐and‐red howlers. The results show that the black‐and‐red howler monkey has a highly rearranged genome and that the human chromosome homologs are often fragmented and translocated. The number of hybridization signals we obtained per haploid set was 40. Nine human chromosome probes gave multiple signals on different howler chromosomes, showing that their synteny is disturbed in A. Belzebul. Fourteen black‐and‐red howler autosomes were completely hybridized by one human autosomal paint, six had two signals, three had three signals, and one chromosome had four signals. Howler chromosomes with multiple signals have produced 12 chromosomal syntenies or hybridization associations which differ from those found in humans: 1/2, 2/20, 3/21, 4/15, 4/16, 5/7, 5/11, 8/18, 9/12, 10/16, 14/15, and 15/22. The hybridization pattern was then compared with those found in two red howler taxa and other mammals. The comparison shows that even within the genus Alouatta numerous interchromosomal rearrangements differentiate each taxa: A. belzebul has six unique apomorphic associations, A. seniculus sara and A. seniculus arctoidea share seven derived associations, and additionally A. seniculus sara has four apomorphic associations and A. seniculus arctoideaseven apomorphic associations. A. belzebul appears to have a more conserved karyotype than the red howlers. Both red and black‐and‐red howlers are characterized by Y‐autosome translocations; the peculiar chromosomal sex system found in the red howler taxa could be considered a further transformation of the A. belzebul sex system. The finding that apparently morphologically similar or even identical taxa have such extreme genomic differences has important implications for speciation theory and neotropical primate conservation. Am. J. Primatol. 46:119–133, 1998. © 1998 Wiley‐Liss, Inc.

show abstract

ZOO-FISH analysis: cat and human karyotypes closely resemble the putative ancestral mammalian karyotype

Cited by 125 publications

References 21 publications

In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons

In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons

Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

In situ hybridization (FISH) maps chromosomal homologies between Alouatta belzebul (Platyrrhini, Cebidae) and other primates and reveals extensive interchromosomal rearrangements between howler monkey genomes

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