Zonisamide

Sills, Graeme J.

doi:10.1016/b978-008055232-3.64408-3

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…It can be observed that the maximum change of light intensity increases with CO 2 concentration from 0.03% to 11.5% with a Langmuir-like behavior (R 2 = 0.9986). This concentration range sufficiently covers the need of breath CO 2 analysis for medical applications, which typically ranges between 2.5 and 5.0% in healthy individuals [30]. …”

Section: Resultsmentioning

confidence: 99%

A novel real-time carbon dioxide analyzer for health and environmental applications

Zhao

Miller

Xian

et al. 2014

Sensors and Actuators B: Chemical

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To be able to detect carbon dioxide (CO2) with high accuracy and fast response time is critical for many health and environmental applications. We report on a pocket-sized CO2 sensor for real-time analysis of end-tidal CO2, and environmental CO2. The sensor shows fast and reversible response to CO2 over a wide concentration range, covering the needs of both environmental and health applications. It is also immune to the presence of various interfering gases in ambient or expired air. Furthermore, the sensor has been used for real-time breath analysis, and the results are in good agreement with those from a commercial CO2 detector.

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Section: Resultsmentioning

confidence: 99%

A novel real-time carbon dioxide analyzer for health and environmental applications

Zhao

Miller

Xian

et al. 2014

Sensors and Actuators B: Chemical

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Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs

Wang

Yang

2022

Polypharmacology

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Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii

et al. 2021

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The emergence of multi-drug resistant pathogenic bacteria represents a serious and growing threat to national healthcare systems. Most pressing is an immediate need for the development of novel antibacterial agents to treat Gram-negative multi-drug resistant infections, including the opportunistic, hospital-derived pathogen, Acinetobacter baumannii. Herein we report a naturally occurring 1,2-benzisoxazole with minimum inhibitory concentrations as low as 6.25 μg ml−1 against clinical strains of multi-drug resistant A. baumannii and investigate its possible mechanisms of action. This molecule represents a new chemotype for antibacterial agents against A. baumannii and is easily accessed in two steps via de novo synthesis. In vitro testing of structural analogs suggest that the natural compound may already be optimized for activity against this pathogen. Our results demonstrate that supplementation of 4-hydroxybenzoate in minimal media was able to reverse 1,2-benzisoxazole’s antibacterial effects in A. baumannii. A search of metabolic pathways involving 4-hydroxybenzoate coupled with molecular modeling studies implicates two enzymes, chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyltransferase, as promising leads for the target of 3,6-dihydroxy-1,2-benzisoxazole.

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Zonisamide

Cited by 3 publications

References 13 publications

A novel real-time carbon dioxide analyzer for health and environmental applications

A novel real-time carbon dioxide analyzer for health and environmental applications

Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs

Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii

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