Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment.

Gorgas, Karin; Krisans, Skaidrite K.

doi:10.1016/s0022-2275(20)38198-0

Cited by 29 publications

(3 citation statements)

References 34 publications

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“…Induction of the Abcd2 and Aox expression and of the peroxisome proliferation in the liver of rats was moderate and occurred only after a long-term (6-9-wk) treatment with high doses of PBA. The observed alterations in the shape (phi-bodies) and in the distribution (clusters and nearly touching organelles) of peroxisomes are reminiscent of PP-induced modifications already described in rat liver (Svoboda and Azarnoff, 1966;Baumgart et al, 1989;Gorgas and Krisans, 1989;Roels, 1991) and rat hepatoma cells (Duclos et al, 1997). It has been shown that overexpression of Pex11p in rodent or human cells causes peroxisome proliferation, characterized by initial conversion of peroxisomes from spherical vesicles into elongated tubules followed by appearance of numerous small vesicular peroxisomes (Passreiter et al, 1998;Schrader et al, 1998;.…”

Section: Discussionsupporting

confidence: 58%

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Gondcaille

Depreter

Fourcade

et al. 2005

The Journal of Cell Biology

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X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disease due to mutations in the ABCD1 (ALD) gene, encoding a peroxisomal ATP-binding cassette transporter (ALDP). Overexpression of adrenoleukodystrophy-related protein, an ALDP homologue encoded by the ABCD2 (adrenoleukodystrophy-related) gene, can compensate for ALDP deficiency. 4-Phenylbutyrate (PBA) has been shown to induce both ABCD2 expression and peroxisome proliferation in human fibroblasts. We show that peroxisome proliferation with unusual shapes and clusters occurred in liver of PBA-treated rodents in a PPARα-independent way. PBA activated Abcd2 in cultured glial cells, making PBA a candidate drug for therapy of X-ALD. The Abcd2 induction observed was partially PPARα independent in hepatocytes and totally independent in fibroblasts. We demonstrate that a GC box and a CCAAT box of the Abcd2 promoter are the key elements of the PBA-dependent Abcd2 induction, histone deacetylase (HDAC)1 being recruited by the GC box. Thus, PBA is a nonclassical peroxisome proliferator inducing pleiotropic effects, including effects at the peroxisomal level mainly through HDAC inhibition.

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Section: Discussionsupporting

confidence: 58%

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Gondcaille

Depreter

Fourcade

et al. 2005

The Journal of Cell Biology

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“…The current investigation has described a shift in the lobular distribution of the induced hepatic DNA synthesis that occurs following exposure of rats to DEHP Chemically induced hepatic proliferation of peroxisomes has been shown to be differentially distributed across the liver lobule, at least at dose levels that are low enough to demonstrate selectivity (4,9,22). The critical factor that determines a carcinogenic response of a chemical may not, therefore, simply be an overall induction of peroxisomes or of hepatic DNA synthesis but rather is selective induction of DNA synthesis in &dquo;high-risk&dquo; areas, or cells, of the liver, where metabolic activity, in some currently unknown way, may pose an increased chance that defect will occur during the process.…”

Section: Discussionmentioning

confidence: 87%

Quantitative Analysis of the Lobular Distribution of S-Phase in Rat Liver Following Dietary Administration of Di(2-ethylhexyl)phthalate

et al. 1999

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A simple image-analysis method is described, whereby the distribution of hepatocytes that have entered S-phase, as distinguished by the incorporation of bromodeoxyuridine, can be related to the position of the central and portal veins of the hepatic lobule. Hepatocyte S-phase was induced in the livers of male and female F344 rats by administration of di(2-ethylhexyl)phthalate (DEHP) in the diet for 7 days at 2 dose levels, and these livers were used to develop the procedure. The distributions of the S-phase between control and DEHP-treated livers were compared using statistical techniques. The results showed notable differences in the distribution of S-phase between male and female rats as well as limited dose-related effects.

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“…Crystalline matrical inclusions are a common feature of peroxisomes from many different sources (for reviews see Hruban and Rechcigl, 1969;B6ck et al, 1980). Inclusions occur either genuinely, or are induced (Veenhuis and Harder, 1987;Gorgas and Krisans, 1989). Hitherto only two types of inclusions have been isolated and studied in detail.…”

Section: Matrical Inclusions In Peroxisomesmentioning

confidence: 99%

Purification of marginal plates from bovine renal peroxisomes: identification with L-alpha-hydroxyacid oxidase B.

Zaar

Völkl

Fahimi

1991

The Journal of Cell Biology

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Abstract. The matrix of mammalian peroxisomes frequently contains crystalline inclusions. The most common inclusions are membrane associated plate-like "marginal plates" of hitherto unknown nature in renal peroxisomes and central polytubular "cores" composed of urate oxidase in hepatic peroxisomes. In bovine kidney, peroxisomes of proximal tubules exhibit peculiar angular shapes that are caused by multiple marginal plates (Zaar, K., and H. D. Fahimi. 1990. Cell l~ssue Res. 260:409-414). Enriched or highly purified peroxisome preparations from this source were used to purify and characterize marginal plates. By SDS-PAGE, one major polypeptide of Mr 33,500 was observed that corresponded to the marginal plate protein. This polypeptide was identified by its enzymatic activity as well as by immunoblotting and preembedding immunocytochemistry as the isozyme B of L-Othydroxyacid oxidase (EC 1.4.3.2). Morphologically, marginal plates were revealed to consist of rectangular straight-edged sheets, exhibiting a defined crystalline lattice structure. The sheets apparently are composed of a single layer of protomers which associate laterally to form a plate-like structure. As deduced from the negative staining results and the additional information of the thickness of marginal plates, each protomer seems to consist of eight subunits forming a cube-like array. The tendency of L-ot-hydroxyacid oxidase B to self-associate in vitro (Philips, D. R., J. A. Duley, D. J. Fennell, and R. S. Holmes. 1976. Biochim. Biophys. Acta. 427:679-687) corresponds to the mode of association of cubical protomers to form the so-called marginal plates in renal peroxisomes.

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Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment.

Cited by 29 publications

References 34 publications

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Quantitative Analysis of the Lobular Distribution of S-Phase in Rat Liver Following Dietary Administration of Di(2-ethylhexyl)phthalate

Purification of marginal plates from bovine renal peroxisomes: identification with L-alpha-hydroxyacid oxidase B.

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