Zolpidem and triazolam do not affect the nocturnal sleep-induced memory improvement

Meléndez, Jaime; Galli, Irina; Boric, Katica; Ortega, Alonso; Zuñiga, Leonardo; Henríquez-Roldán, Carlos; Cárdenas, Ana Marı́a

doi:10.1007/s00213-005-2228-0

Cited by 18 publications

(11 citation statements)

References 58 publications

(51 reference statements)

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“…However, the few studies concentrating on memory consolidation during sleep point towards opposite effects. Early experiments in healthy volunteers suggested an impairing influence of the benzodiazepine trialzolam and the non-benzodiazepine zopiclone administered after learning before sleep on the retention of words (1040,1082), whereas one study did not find an impairing effect of the hypnotics zolpidem and triazolam on sleep-dependent memory consolidation of words and nonwords (813). Administration of the GABA B agonists sodium oxybate or baclofen before a nap increased SWS, without affecting sleep-dependent declarative memory consolidation of word pairs and face-location associations (1255).…”

Section: Gabamentioning

confidence: 97%

“…Since the cholinergic neurons mediating the recurrent inhibition in hippocampus receive strong inhibitory GABAergic inputs, strengthening this GABAergic activity should enhance hippocampal memory reactivation. This mechanism could explain why postlearning administration of benzodiazepines improves memory consolidation in waking subjects but not during SWS when cholinergic activity is already minimal (454,813).…”

Section: Neuromodulation Associated With Sleep and Sws And Memory Prmentioning

confidence: 99%

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About Sleep's Role in Memory

Rasch

Born

2013

Physiological Reviews

2,234

2,026

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Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

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Section: Gabamentioning

confidence: 97%

Section: Neuromodulation Associated With Sleep and Sws And Memory Prmentioning

confidence: 99%

About Sleep's Role in Memory

Rasch

Born

2013

Physiological Reviews

2,234

2,026

View full text Add to dashboard Cite

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“…Number of studies suggest that zolpidem in the dose of 5 to 10 mg is safe even for longer treatment periods of up to 35 days to 3 months of treatment [62,63]. It has also been shown not to interfere with the nocturnal sleep‐induced improvement of memory [64]. Also, in one other study insomniac patients tended to prefer zolpidem to zaleplon on both nocturnal and diurnal assessments in a randomized, double‐blind, crossover study done on 53 patients [65].…”

Section: Zolpidemmentioning

confidence: 99%

Role of Zolpidem in the Management of Insomnia

Dang

Garg

Rataboli

2011

CNS Neuroscience & Therapeutics

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Insomnia is a common condition that affects one's ability to sleep comfortably and consequently to work effectively. Its etiology is multifactorial and involves plethora of risk factors. Consequences can vary from mild sleepiness to more sever psychiatric disturbances and ischemic stroke. Despite several diagnostic criteria it is poorly diagnosed and less often treated. Benzodiazepines formed the mainline therapy for many years till the advent of newer nonbenzodiazepine group of drugs including zolpidem. Zolpidem is an imidazo-pyridine compound that enhances the GABA(A) receptor function by interaction with Omega-1 receptor subtype. Its pharmacokinetic profile allows the patients to use it later in the night when having trouble falling asleep without any residual cognitive impairment the next morning. It has rapid onset of action, improves total sleep duration, and reduces night-time awakenings. Its adverse effect profile is satisfactory as it appears to have low addiction potential. This review will focus on the current role of zolpidem in the management of insomnia.

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“…Melendez et al reported no effect of either zolpidem immediate release (10 mg) or triazolam (0.25 mg) on SDMC in normal sleepers. 19 However, subjects were trained to 100% on the memory tasks prior to the sleep period precluding a demonstration that the tests used were sensitive to SDMC with placebo. Other investigators found that zopiclone (7.5 mg), but not brotizolam (0.25 mg), impaired SDMC in normals.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Two Benzodiazepine Receptor Agonist Hypnotics on Sleep-Dependent Memory Consolidation

Hall-Porter

Schweitzer

Eisenstein

et al. 2014

Journal of Clinical Sleep Medicine

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Results: ANOVA revealed a signifi cant condition effect for the WPT (p = 0.025) and a trend for the FTT (p = 0.067), which was signifi cant when sex was added to the model (p = 0.014). Improvement in memory performance following sleep was lower with bedtime dosing of zolpidem-ER compared to placebo and middle-of-the-night dosing of zaleplon. There were no differences between placebo and zaleplon. Conclusions:The results suggest that in some circumstances hypnotics may have the potential to reduce the degree of sleep-dependent memory consolidation and that drug-free sleep early in the night may ameliorate this effect. S C I E N T I F I C I N V E S T I G A T I O N SA growing body of evidence demonstrates that sleep promotes memory consolidation in healthy individuals.1-3 Numerous studies using various designs and memory tasks have consistently found that memory consolidation (i.e., improvement on a given memory task from initial training/test to retest) is significantly greater after a period of sleep than a period of wake. This is commonly referred to as sleep-dependent memory consolidation (SDMC). 4 For example, improvements on a procedural memory fi nger-tapping task were observed after a night of sleep but not after 4-, 8-, or 12-hour daytime periods without sleep. 5,6 Studies examining declarative memory consolidation, such as with a word pair association task, also demonstrate improvements in performance after sleep.7 In addition to improvements in memory following overnight sleep, memory consolidation is also enhanced during naps as short as 45 minutes. Improvements in procedural 8,9 and declarative 10 memory occur with naps, but not following similar durations of wakefulness. These fi ndings suggest that memory consolidation that occurs during wakefulness is enhanced during sleep.Synaptic plasticity, which refers to structural or functional neural changes in response to stimuli, 2 is thought to be the cellular substrate underlying the processes of memory formation and consolidation.11 Sleep has been found to enhance plasticity in animals, 12 which is consistent with the idea that sleep enhances memory consolidation. In humans, fMRI studies have shown that sleep-dependent learning of a motor skill task is accompanied by changes in multiple brain areas, BRIEF SUMMARYCurrent Knowledge/Study Rationale: Few studies have investigated the impact of hypnotic medication on sleep-dependent memory consolidation. This study compared the effect of differing time of exposure to two hypnotics on the sleep-dependent consolidation of declarative and non-declarative memory. Study Impact: This study contributes to the research surrounding sleep-dependent memory and hypnotics, indicating that hypnotic exposure during most of the night may reduce sleep-dependent memory consolidation; whereas hypnotic exposure only during the second half of the night appears to have no effect.

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Zolpidem and triazolam do not affect the nocturnal sleep-induced memory improvement

Abstract: The hypnotics tested did not interfere with the nocturnal sleep-induced improvement of memory.

Cited by 18 publications

References 58 publications

About Sleep's Role in Memory

About Sleep's Role in Memory

Role of Zolpidem in the Management of Insomnia

The Effect of Two Benzodiazepine Receptor Agonist Hypnotics on Sleep-Dependent Memory Consolidation

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