Zollinger-Ellison syndrome. Report of a case

Loughridge, James S.; Neill, D. W.; Willis, John

doi:10.1002/bjs.18004820815

Cited by 8 publications

(1 citation statement)

References 4 publications

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“…In 2 other patients (F, 49; M, 27) removal of apparently single adenomas failed to restore the plasma gastrin levels to normal, but ulceration was controlled by cimetidine. The fifth patient (F, 46) had a large malignant tumor in the pancreatic tail and died postoperatively [14].…”

Section: Endocrine Syndromesmentioning

confidence: 99%

Neuroendocrine tumors of the gut

et al. 1985

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Of 75 patients with neuroendocrine tumors of the gut, 50 had functioning lesions, causing endocrine syndromes. These included 16 insulinomas, 13 gastrinomas, 5 vipomas (4 pancreatic, 1 adrenal), 4 corticotrophinomas, and 1 renal enteroglucagonoma. Three patients had mixed endocrine syndromes. Eight or 9 patients with pancreatic lesions had multiple endocrine adenopathy (MEA I), including 3 of 4 patients with multiple insulinomas and all 3 patients with malignant gastrinomas. Localization of the pancreatic insulinomas, vipomas, and mixed tumors by arteriography was excellent, but few gastrinomas were detected before operation. Eight patients developed the malignant carcinoid syndrome with metastases from primary tumors in the ileum (6 patients), bronchus, and stomach. Hepatic artery embolization provided palliative relief for several with this and some other syndromes. Twenty‐five patients had tumors that caused nonspecific features only. These included 18 appendicular carcinoids, 5 islet cell carcinomas, and 2 other apudomas (1 hepatic and 1 whose primary site is unknown). The importance of the latter is that they are more responsive to therapy and have a better prognosis than the more common acinar tumors. Over 40% of the patients had lesions that were cured surgically and over 80% obtained some benefit from treatment.

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Section: Endocrine Syndromesmentioning

confidence: 99%