Zoledronic Acid Is Superior to Pamidronate in the Treatment of Hypercalcemia of Malignancy: A Pooled Analysis of Two Randomized, Controlled Clinical Trials

Abstract

Zoledronic acid is superior to pamidronate; 4 mg is the dose recommended for initial treatment of HCM and 8 mg for relapsed or refractory hypercalcemia.

Comparison of Fc-osteoprotegerin and zoledronic acid activities suggests that zoledronic acid inhibits prostate cancer in bone by indirect mechanisms

“…8 ZA is a new-generation BP and a very potent inhibitor of bone lysis. 9 The value and potential of ZA in treatment of patients with cancer-related bone disease were recently reviewed. 10 In addition to inhibition of osteolysis, several studies have shown that BPs, including ZA, exhibit direct anti-tumor effects in vitro.…”

Symptom Management in Metastatic Breast Cancer

“…The use of a loop diuretic is not necessary except to treat edema or volume overload [76]. In a pooled analysis of two randomized controlled trials, zoledronic acid (4 mg) resulted in a response rate superior to that with pamidronate (90 mg), and this is the recommended agent for initial treatment; for those with refractory hypercalcemia, 8 mg is recommended [77]. In addition to the above, for patients who are symptomatic with severe hypercalcemia, calcitonin may also be considered, recognizing that tachyphylaxis to this agent occurs within 48 hours [78].…”

Hospital management of self harm in adults in England

“…Experienced doctors treating hypercalcaemia of malignancy commonly use doses of 60-90 mg pamidronate for a calcium concentration around 3.0 mmol/l, and the Novartis sponsored study comparing zoledronic acid and pamidronate in patients with values ≥ 3.0 mmol/l used 90 mg pamidronate. 1 Although failure to comply with prescribing recommendations may have contributed to the effects seen in our cases, the inability to mount a normal physiological response as described played a large part in the severe hypocalcaemia.…”

“…1 3 This makes no exception for computerised dissemination undermining confidentiality between professional and client. The authors' second paper, on data quality, considers coding and data unavailability, but not accuracy.…”