Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7

Liu, Shuang; Sahid, Muhammad Novrizal Abdi; Takemasa, Erika; Maeyama, Kazutaka; Mogi, Masaki

doi:10.1016/j.bcp.2018.02.013

Cited by 8 publications

(10 citation statements)

References 29 publications

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“…5) Previously, simvastatin was shown to disturbed Rab27a/Doc2a interaction. 6) Here we extend the study by Liu et al 4) to investigate whether zoledronate also disturbs Rab27a/Doc2a interaction during MC activation.…”

Section: Introductionsupporting

confidence: 58%

“…All the experimental procedures performed in this study are available in Sahid et al 6) and Liu et al 4) Brief explanations are described below.…”

Section: Methodsmentioning

confidence: 99%

“…3) The recent finding showed that via this mechanism, zoledronate prevents histamine release (HR) from RBL-2H3 cell that was activated by a variation of secretagogues, i.e., antigen and ionomycin. 4) Zoledronate inhibition of HR involves the disturbance of Rab3a/ myosinVa. 4) Mast cells (MCs) exocytosis is arranged by many Rab proteins, including Rab3a, Rab27a, and Rab11.…”

Section: Introductionmentioning

confidence: 99%

“…4) Zoledronate inhibition of HR involves the disturbance of Rab3a/ myosinVa. 4) Mast cells (MCs) exocytosis is arranged by many Rab proteins, including Rab3a, Rab27a, and Rab11. 5) Previously, simvastatin was shown to disturbed Rab27a/Doc2a interaction.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction

Sahid

Liu

Kiyoi

et al. 2021

Biological & Pharmaceutical Bulletin

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Section: Introductionsupporting

confidence: 58%

“…All the experimental procedures performed in this study are available in Sahid et al 6) and Liu et al 4) Brief explanations are described below.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction

Sahid

Liu

Kiyoi

et al. 2021

Biological & Pharmaceutical Bulletin

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“…In human immune cells, both VAMP7 and VAMP8 have been shown to form a SNARE complex with Syntaxin4 and SNAP-23 that mediates activation-induced degranulation of mast cells (31, 43). In human eosinophils and neutrophils, VAMP7 also interacts with Syntaxin4 and SNAP-23 to enable the release of mediators (44, 45).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7

et al. 2019

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Cytotoxic T lymphocytes kill infected or malignant cells through the directed release of cytotoxic substances at the site of target cell contact, the immunological synapse. While genetic association studies of genes predisposing to early-onset life-threatening hemophagocytic lymphohistiocytosis has identified components of the plasma membrane fusion machinery, the identity of the vesicular components remain enigmatic. Here, we identify VAMP7 as an essential component of the vesicular fusion machinery of primary, human T cells. VAMP7 co-localizes with granule markers throughout all stages of T cell maturation and simultaneously fuses with granule markers at the IS. Knock-down of VAMP7 expression significantly decreased the killing efficiency of T cells, without diminishing early T cell receptor signaling. VAMP7 exerts its function in a SNARE complex with Syntaxin11 and SNAP-23 on the plasma membrane. The identification of the minimal fusion machinery in T cells provides a starting point for the development of potential drugs in immunotherapy.

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A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis

Suzuki

Liu

Ogasawara

et al. 2020

European Journal of Pharmacology

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Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7

Cited by 8 publications

References 29 publications

Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction

Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction

Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7

A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis

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