Zoanthid mucus as new source of useful biologically active proteins

Guarnieri, M.C.; Modesto, Jeanne Claine de Albuquerque; Pérez, Carlos Daniel; Ottaiano, Tatiana F.; Ferreira, Rodrigo S.; Batista, Fabrício Pereira; Brito, Marlon Vilela de; Campos, Ikaro Henrique Mendes Pinto; Oliva, Maria Luiza Vilela

doi:10.1016/j.toxicon.2018.01.012

Cited by 8 publications

(4 citation statements)

References 77 publications

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“…All these immunological responses are located within live tissues, but there have been no assessments of immunological activity of the mucus layer in Cnidarians. However, a recent study of untreated mucus collected from the reef zoanthid Palythoa caribaeorum indicated the presence of bioactive compounds like lectins and proteolytic enzymes (Camargo Guarnieri et al, 2018). Further, scleractinian corals release some antibacterial compounds upon mechanical stress (Greffen and Rosenberg, 2005).…”

Section: Introductionmentioning

confidence: 99%

Contrasting Antibacterial Capabilities of the Surface Mucus Layer From Three Symbiotic Cnidarians

Rivera-Ortega

Thomé

2018

Front. Mar. Sci.

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Section: Introductionmentioning

confidence: 99%

Contrasting Antibacterial Capabilities of the Surface Mucus Layer From Three Symbiotic Cnidarians

Rivera-Ortega

Thomé

2018

Front. Mar. Sci.

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“…Venomous creatures are considered to be a very distinctive class of species among animals [22]. Venomous animals are equipped with venom glands and venoms, which provide them outstanding advantages for their existence [24][25][26]. Toxins from centipedes have been well studied.…”

Section: Discussionmentioning

confidence: 99%

Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum

Luan

Zhao

Duan

et al. 2019

Toxins

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Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors. When elastase and its inhibitors are out of balance, severe diseases will develop, especially those involved in the cardiopulmonary system. Much attention has been attracted in seeking innovative elastase inhibitors and various advancements have been taken on clinical trials of these inhibitors. Natural functional peptides from venomous animals have been shown to have anti-protease properties. Here, we identified a kazal-type serine protease inhibitor named ShSPI from the cDNA library of the venom glands of Scolopendra hainanum. ShSPI showed significant inhibitory effects on porcine pancreatic elastase and human neutrophils elastase with Ki values of 225.83 ± 20 nM and 12.61 ± 2 nM, respectively. Together, our results suggest that ShSPI may be an excellent candidate to develop a drug for cardiopulmonary diseases.

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“…Under aerobic conditions the bacterium Pseudoalteromonas tunicata forms pseudomorphs surrounding marine embryos, whereas anaerobic conditions result in the destruction and decay of the internal structures of the cells (Raff et al ., 2014). Moreover, many cnidaria are sessile marine organisms that are rarely capable of locomotion, so they secrete mucus (viscoelastic adhesive gel) to reduce water loss, enable adsorption to surfaces and also – due to various antimicrobial molecules – to protect against bacterial pathogens (Guarnieri et al ., 2018; Mariottini & Grice, 2016; Stabili et al ., 2015). Thereby, the cnidarian host is able actively to select beneficial bacterial partners and drive the microbial community composition (Franzenburg et al ., 2013).…”

Section: Case Studiesmentioning

confidence: 99%

The complex role of microbial metabolic activity in fossilization

Janssen¹,

Mähler

Rust

et al. 2021

Biological Reviews

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Bacteria play an important role in the fossilization of soft tissues; their metabolic activities drive the destruction of the tissues and also strongly influence mineralization. Some environmental conditions, such as anoxia, cold temperatures, and high salinity, are considered widely to promote fossilization by modulating bacterial activity. However, bacteria are extremely diverse, and have developed metabolic adaptations to a wide range of stressful conditions. Therefore, the influence of the environment on bacterial activity, and of their metabolic activity on fossilization, is complex. A number of examples illustrate that simple, general assumptions about the role of bacteria in soft tissue fossilization cannot explain all preservational pathways: (i) experimental results show that soft tissues of cnidaria decay less in oxic than anoxic conditions, and in the fossil record are found more commonly in fossil sites deposited under oxic conditions rather than anoxic environments; (ii) siderite concretions, which often entomb soft tissue fossils, precipitate due to a complex mixture of sulfate‐ and iron reduction by some bacterial species, running counter to original theories that iron reduction is the primary driver of siderite concretion growth; (iii) arthropod brains, now widely accepted to be preserved in many Cambrian fossil sites, are one of the first structures to decay in taphonomic experiments, indicating that their fossilization processes are complex and influenced by bacterial activity. In order to expand our understanding of the complex process of bacterially driven soft tissue fossilization, more research needs to be done, on fossils themselves and in taphonomic experiments, to determine how the complex variation in microbial metabolic activity influences decay and mineralization.

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Zoanthid mucus as new source of useful biologically active proteins

Cited by 8 publications

References 77 publications

Contrasting Antibacterial Capabilities of the Surface Mucus Layer From Three Symbiotic Cnidarians

Contrasting Antibacterial Capabilities of the Surface Mucus Layer From Three Symbiotic Cnidarians

Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum

The complex role of microbial metabolic activity in fossilization

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