ZO-1 expression shows prognostic value in chronic B cell leukemia

Nesmiyanov, Pavel P.; Tolkachev, B. E.; Стрыгин, А. В.

doi:10.1016/j.imbio.2015.08.008

Cited by 3 publications

(2 citation statements)

References 37 publications

(38 reference statements)

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“…However, the role of Cx43 in KIRC has rarely been reported. Emerging evidence has confirmed that Cx43 can act as a tumor suppressor in gastric cancer, melanoma, pancreatic cancer, lung cancer, chronic B-cell leukemia, prostate cancer, breast cancer, and thyroid cancer [9,[15][16][17][18][20][21][22][23]. However, it should be noted that Cx43 can also promote invasion and metastasis in triple-negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and astrocytoma [50][51][52].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Cx43 expression has been observed to be associated with both cancer promotion and suppression, exerting significant influences on carcinogenesis, cancer progression, and metastasis [14]. For example, previous studies have shown that Cx43 expression was significantly decreased in gastric cancer, melanoma cancer [15], pancreatic cancer [16,17], lung cancer [18,19], chronic B-cell leukemia [20], prostate cancer [21], breast cancer [22][23][24][25], and thyroid cancer [9]. In addition, higher levels of Cx43 expression promoted metastasis [26][27][28] in many cancers, such as gastric cancer, melanoma, some brain cancers (astrocytoma, glioma) [29,30], breast tumors [22,23,25,31,32], and prostate cancer bone metastasis [21].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive Pan-Cancer Analysis of Connexin 43 as a Potential Biomarker and Therapeutic Target in Human Kidney Renal Clear Cell Carcinoma (KIRC)

Xu,

Wang,

Zhu

et al. 2024

Medicina

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Background and Objectives: Connexin 43 (Cx43) is involved in the transfer of small signaling molecules between neighboring cells, thereby exerting a major influence on the initiation and progression of tumorigenesis. However, there is a lack of systematic research on Cx43 expression and its predictive role in clinical diagnosis and prognosis in pan-cancer. Materials and Methods: Several biological databases were used to evaluate the expression levels of GJA1 (encoding Cx43) and its diagnostic and prognostic significance in pan-cancer. We targeted kidney renal clear cell carcinoma (KIRC) and investigated the relationship between GJA1 expression and different clinical features of KIRC patients. Then, we performed cell-based experiments to partially confirm our results and predicted several proteins that were functionally related to Cx43. Results: The expression of GJA1 has a high level of accuracy in predicting KIRC. High GJA1 expression was remarkably correlated with a favorable prognosis, and this expression was reduced in groups with poor clinical features in KIRC. Cell experiments confirmed the inhibitory effects of increased GJA1 expression on the migratory capacity of human renal cancer (RCC) cell lines, and protein–protein interaction (PPI) analysis predicted that CDH1 and CTNNB1 were closely related to Cx43. Conclusions: GJA1 could be a promising independent favorable prognostic factor for KIRC, and upregulation of GJA1 expression could inhibit the migratory capacity of renal cancer cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comprehensive Pan-Cancer Analysis of Connexin 43 as a Potential Biomarker and Therapeutic Target in Human Kidney Renal Clear Cell Carcinoma (KIRC)

Xu,

Wang,

Zhu

et al. 2024

Medicina

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Connexin 43 (Cx43) in cancer: Implications for therapeutic approaches via gap junctions

Bonacquisti

Nguyen

2019

Cancer Letters

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"Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma

et al. 2017

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Here we describe isolation and characterization of macrophage-tumor cell fusions (MTFs) from the blood of pancreatic ductal adenocarcinoma (PDAC) patients. The MTFs were generally aneuploidy, and immunophenotypic characterizations showed that the MTFs express markers characteristic of PDAC and stem cells, as well as M2-polarized macrophages. Single cell RNASeq analyses showed that the MTFs express many transcripts implicated in cancer progression, LINE1 retrotransposons, and very high levels of several long non-coding transcripts involved in metastasis (such as MALAT1). When cultured MTFs were transplanted orthotopically into mouse pancreas, they grew as obvious well-differentiated islands of cells, but they also disseminated widely throughout multiple tissues in “stealth” fashion. They were found distributed throughout multiple organs at 4, 8, or 12 weeks after transplantation (including liver, spleen, lung), occurring as single cells or small groups of cells, without formation of obvious tumors or any apparent progression over the 4 to 12 week period. We suggest that MTFs form continually during PDAC development, and that they disseminate early in cancer progression, forming “niches” at distant sites for subsequent colonization by metastasis-initiating cells.

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ZO-1 expression shows prognostic value in chronic B cell leukemia

Cited by 3 publications

References 37 publications

Comprehensive Pan-Cancer Analysis of Connexin 43 as a Potential Biomarker and Therapeutic Target in Human Kidney Renal Clear Cell Carcinoma (KIRC)

Comprehensive Pan-Cancer Analysis of Connexin 43 as a Potential Biomarker and Therapeutic Target in Human Kidney Renal Clear Cell Carcinoma (KIRC)

Connexin 43 (Cx43) in cancer: Implications for therapeutic approaches via gap junctions

"Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma

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