ZNT1 involves cuproptosis through regulating MTF1-conduced expression of MT1X under copper overload
Yue Wu,
Tingyun Yang,
Bo Yan
et al.
Abstract:Background
Copper is an essential but also toxic heavy metal. As a crucial micronutrient, copper is required for various enzymes in physiology and pathology. Meanwhile, copper overload has currently raised serious public health concerns. Copper overload can perturb intracellular homeostasis and induce oxidative stress and even cell death. More recently, cuproptosis has been identified as a copper-dependent form of cell death induced by oxidative stress in mitochondria. This mitochondrial cell death is charact… Show more
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